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Titolo:
THROMBOEMBOLISM IN PATIENTS WITH HIGH-GRADE GLIOMA
Autore:
QUEVEDO JF; BUCKNER JC; SCHMIDT JL; DINAPOLI RP; OFALLON JR;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV MED ONCOL,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV MED ONCOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL ROCHESTER MN 00000 MAYO CLIN & MAYO FDN,CANC CTR STAT ROCHESTER MN 00000
Titolo Testata:
Mayo Clinic proceedings
fascicolo: 4, volume: 69, anno: 1994,
pagine: 329 - 332
SICI:
0025-6196(1994)69:4<329:TIPWHG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL HIP-REPLACEMENT; VENOUS THROMBOEMBOLISM; PROPHYLAXIS; THROMBOSIS; ASPIRIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Quevedo et al., "THROMBOEMBOLISM IN PATIENTS WITH HIGH-GRADE GLIOMA", Mayo Clinic proceedings, 69(4), 1994, pp. 329-332

Abstract

Objective: To identify factors related to increased or decreased riskof thromboembolism (TE) in patients with high-grade glioma. Design: We performed a retrospective analysis of 64 patients enrolled in two prospective clinical trials of chemotherapy and radiation therapy for newly diagnosed high-grade glioma. Material and Methods: The 64 patientsmere 18 years of age or older and had histologically confirmed grade 3 or 4 astrocytoma, mixed astrocytoma-oligodendroglioma, or gliosarcoma. The diagnosis of TF was confirmed by impedance plethysmography, venography, duplex ultrasonography, ventilation-perfusion lung scanning, or pulmonary angiography. For statistical analysis, the study group was divided into those with and those without TE. Results: TE developed in 18 of the 64 patients (28%). Of the 18 patients, 11 had deep venousthrombosis of a lower extremity, 5 had pulmonary emboli, and 2 had superficial thrombophlebitis. A paretic arm (P = 0.017), a paretic leg (P = 0.026), or a history of TE before the diagnosis of glioma (P = 0.076) was more common in patients with TE than in those without TE. Ten patients in the group without TE were using aspirin preoperatively in comparison with no patient in the TE group (P = 0.05). No significant differences mere noted in duration of survival (median, 39.4 weeks and46 weeks for the TE and non-TE groups, respectively). One patient with apparently excessive anticoagulation had a fatal intracerebral hemorrhage. Conclusion: This study suggests that TE in patients with newly diagnosed high-grade glioma might be associated with a history of TE or with a paretic extremity; however, no evidence of worse survival wasnoted in the TE group. Treatment with heparin followed by warfarin sodium was associated with infrequent bleeding complications. An intriguing finding was that the use of aspirin before operation was associated with a decreased risk of TE. Thus, a prospective study with use of aspirin in patients with high-grade glioma at risk for TE would be reasonable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 08:11:30