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Titolo:
FETAL TRANSPLANTS IN RAT HIPPOCAMPUS FOLLOWING KAINIC ACID LESIONS - INFLUENCE OF POSTLESION DELAY ON GRAFT-SURVIVAL AND INTEGRATION
Autore:
PYAPALI GK; TURNER DA; MADISON RD;
Indirizzi:
DUKE UNIV,MED CTR,DEPT SURG NEUROSURG,BOX 3807 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT SURG NEUROSURG DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT NEUROBIOL DURHAM NC 27710 VET ADM MED CTR,MED RES SERV DURHAM NC 27710 VET ADM MED CTR,SURG NEUROSURG SERV DURHAM NC 27710
Titolo Testata:
Restorative neurology and neuroscience
fascicolo: 2, volume: 6, anno: 1994,
pagine: 113 - 126
SICI:
0922-6028(1994)6:2<113:FTIRHF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACEREBRAL NEURAL IMPLANTS; SYNAPTIC POTENTIALS; CA3-CA4 AFFERENTS; STRIATAL GRAFTS; PYRAMIDAL CELLS; FASCIA DENTATA; NEURONS; BRAIN; CA1; ORGANIZATION;
Keywords:
KAINIC ACID LESION; POSTLESION DELAY; FETAL NEURAL GRAFT; FLUORESCENT LABEL; HIPPOCAMPUS; NEURONAL STRUCTURE; PHYSIOLOGICAL RECORDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
G.K. Pyapali et al., "FETAL TRANSPLANTS IN RAT HIPPOCAMPUS FOLLOWING KAINIC ACID LESIONS - INFLUENCE OF POSTLESION DELAY ON GRAFT-SURVIVAL AND INTEGRATION", Restorative neurology and neuroscience, 6(2), 1994, pp. 113-126

Abstract

Host brain receptivity to fetal hippocampal grafts was investigated following transplantation into unilateral kainic acid (KA) lesions of adult rat hippocampus. E18-E19 hippocampal cell suspensions were labeled with rhodamine dextran amine and transplanted bilaterally into hostsat various times following the KA-lesion. After one to three and one half months survival the grafts (contained within host hippocampal slices) were analyzed using intracellular electrophysiological techniques. A nonparametric graft index was developed which assessed the overallsize and distribution of the graft. Using this grading system graft development was noted to be significantly enhanced for grafts placed into hosts with KA lesions at either 2-4 days or 11-12 days following the lesion, compared to grafts placed at either 6-7 days or 27-33 days after the lesion. Also, grafts implanted at delays of either 14-16 or 28-33 days appeared to have fewer surviving cells but were more dispersed within the host brain than grafts at shorter post-lesion implant times. Synaptic responses to host stimulation were noted in most grafts. Intracellular staining of transplanted neurons showed considerable development of cell processes but atypical pyramidal cell morphology andectopic location; numerous axons traveled into the host tissue. The time course of lesion-induced host receptivity appeared to significantly influence graft development and maturation. In this study graft survival was partially independent from cell migration. This differential effect may be due to various aspects of host brain receptivity, which in turn is influenced by the delay between the host brain lesion and grafting.

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Documento generato il 03/07/20 alle ore 01:02:19