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Titolo:
QUANTITATIVE CONTROL OF OXYTOCIN-INDUCED PGF(2-ALPHA) RELEASE BY PROGESTERONE AND ESTRADIOL IN EWES
Autore:
BEARD AP; HUNTER MG; LAMMING GE;
Indirizzi:
UNIV NOTTINGHAM,FAC AGR & FOOD SCI,AFRC,RES GRP HORMONES & FARM ANIM REPROD NOTTINGHAM LE12 5RD LEICS ENGLAND UNIV NOTTINGHAM,FAC AGR & FOOD SCI,AFRC,RES GRP HORMONES & FARM ANIM REPROD NOTTINGHAM LE12 5RD LEICS ENGLAND
Titolo Testata:
Journal of Reproduction and Fertility
fascicolo: 1, volume: 100, anno: 1994,
pagine: 143 - 150
SICI:
0022-4251(1994)100:1<143:QCOOPR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONCEPTUS SECRETORY PROTEINS; OVARIECTOMIZED EWES; ESTROUS-CYCLE; EARLY-PREGNANCY; LUTEAL REGRESSION; RECEPTOR CONCENTRATIONS; LUTEINIZING-HORMONE; UTERINE SECRETION; ANESTROUS EWES; VENOUS PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
A.P. Beard et al., "QUANTITATIVE CONTROL OF OXYTOCIN-INDUCED PGF(2-ALPHA) RELEASE BY PROGESTERONE AND ESTRADIOL IN EWES", Journal of Reproduction and Fertility, 100(1), 1994, pp. 143-150

Abstract

The effect of oestradiol and progesterone concentrations on the uterine PGF(2 alpha) response to oxytocin was investigated by measuring 13,14-dihydro-15-keto PGF(2 alpha) (PGFM) secretion. One week after ovariectomy, 27 ewes were administered progestagen for 10 days followed by oestradiol for 2 days. Day 0 was designated as the time of the last 'oestrous' oestradiol injection. Six groups of ewes (n = 4) were then treated for 12 days with a high or low dose of progesterone (36 or 12 mgday(-1)) either alone or with a high or low dose of oestradiol (36 or12 mu g day(-1)) administered (in 1 ml of corn oil by i.m. injection,at intervals of 8 h) in a pattern designed to simulate a natural oestrous cycle profile. A control group (n = 3) was given corn oil alone. Ewes were treated with 1 mu g oxytocin (i.v.) on days 4, 8 and 12 of the simulated cycle and plasma was collected for assay of PGFM. An oxytocin-induced PGFM response occurred only on day 12, when the response was suppressed by high doses of progesterone and stimulated by high oestradiol doses. There was a significant effect of progesterone (P < 0.05) and a highly significant effect of oestradiol (P < 0.01) on the pattern of PGFM release in response to oxytocin. Low progesterone/high oestradiol stimulated the largest and most sustained increase in PGFM following oxytocin. There was a significant relationship between the oestradiol:progesterone ratio and the mean PGFM response on day 12 (P < 0.05). This is the first demonstration of a quantitative effect of steroid hormone concentrations on the PGFM response to oxytocin in ewes, and indicates that in early pregnancy, ewes with a high oestradiol:progesterone ratio may generate larger PGF(2 alpha) episodes thus increasing the risk of a failure of the maternal recognition of pregnancy.

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Documento generato il 05/07/20 alle ore 13:09:11