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Titolo:
THE SON GENE ENCODES A CONSERVED DNA-BINDING PROTEIN MAPPING TO HUMAN-CHROMOSOME-21
Autore:
KHAN IM; FISHER RA; JOHNSON KJ; BAILEY MES; SICILIANO MJ; KESSLING AM; FARRER M; KAMALATI T; BULUWELA L; CARRITT B;
Indirizzi:
UNIV LONDON,CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM,FULHAM PALACE RD LONDON W6 8RF ENGLAND UNIV LONDON,CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM LONDON W6 8RF ENGLAND UNIV LONDON,CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT LONDON W6 8RF ENGLAND UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOLEC GENET HOUSTON TX 77030 ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET LONDON W2 1PG ENGLAND UNIV LONDON UNIV COLL,GALTON LAB,MRC,HUMAN BIOCHEM GENET UNIT LONDON NW1 2HE ENGLAND ROYAL CANC HOSP,INST CANC RES,HADDOW LABS SUTTON SM2 5NG SURREY ENGLAND
Titolo Testata:
Annals of Human Genetics
, volume: 58, anno: 1994,
parte:, 1
pagine: 25 - 34
SICI:
0003-4800(1994)58:<25:TSGEAC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CELL LINE; PROTAMINE GENES; SYNDROME REGION; LOCALIZATION; EXPRESSION; CARCINOMA; SEQUENCES; HYBRIDIZATION; POLYMERASE; JUNCTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
I.M. Khan et al., "THE SON GENE ENCODES A CONSERVED DNA-BINDING PROTEIN MAPPING TO HUMAN-CHROMOSOME-21", Annals of Human Genetics, 58, 1994, pp. 25-34

Abstract

We report the identification and characterization of a clone for the DNA binding protein SON, which we have isolated from a human keratinocyte cDNA library. Using this clone we have found that the SON gene is expressed in different cell types and that homologous sequences can bedetected in vertebrate and insect genomic DNA. Using the polymerase chain reaction (PCR) to amplify SON sequences from a panel of somatic cell hybrids we have assigned the gene encoding human SON to chromosome21. By use of hybrids containing regions of chromosome 21 the localization has been refined to 21q 22.1-q22.2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:19:36