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Titolo:
AEROSOL BOLUS DISPERSION IN THE RESPIRATORY-TRACT OF CHILDREN
Autore:
SCHULZ A; TUCH T; BRAND P; SCHULZ H; ERDL R; VONMUTIUS E; REINHARDT D; HEYDER J;
Indirizzi:
GSF,FORSCHUNGSZENTRUM UMWELT & GENUNDHEIT GMBH,PROJEKT INHALAT,POB 1129 D-85758 OBERSCHLEISSHEIM GERMANY UNIV MUNICH,GSF MUNICH GERMANY UNIV MUNICH,CHILDRENS HOSP W-8000 MUNICH GERMANY
Titolo Testata:
Experimental lung research
fascicolo: 2, volume: 20, anno: 1994,
pagine: 119 - 130
SICI:
0190-2148(1994)20:2<119:ABDITR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAYS;
Keywords:
HALF WIDTH; INTRAPULMONARY CONVECTIVE TRANSPORT; MODE SHIFT; STANDARD DEVIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A. Schulz et al., "AEROSOL BOLUS DISPERSION IN THE RESPIRATORY-TRACT OF CHILDREN", Experimental lung research, 20(2), 1994, pp. 119-130

Abstract

To investigate mechanisms of intrapulmonary convective gas transport,aerosol bolus dispersion was measured in 16 healthy children aged 7-11 years. Subjects inhaled SO-mt aerosol boluses consisting of 0.4-mu mdroplets of di(2-ethylhexyl) sebacate suspended in air into volumetric lung depths between 95 and 540 mL. Bolus dispersion was quantified by volumetric bolus half-width and by volumetric standard deviation of particle concentrations. Bolus half-width increased from a mean of 160mt to 360 mt with increasing lung depth, the regression being a powerlaw with art average exponent of 0.48. Standard deviation increased from 68 to 136 mL with the 0.42th power of volumetric penetration. There was no correlation of bolus dispersion with age, body height, or lung function parameters, except for boluses penetrating very deep into the lung where dispersion was weakly related to lung volume. The results obtained in children did not differ from those found in art adult population in art earlier study. It was concluded that airway size per se does not have a strong influence oil bolus dispersion. Rather, parameters of airway geometry may be among the dominating factors influencing the fate of inhaled particles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:52:56