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Titolo:
CARCINOGEN-INDUCED DE-NOVO METHYLATION IN C-MYC EXON-I
Autore:
OKADA G; RYOYAMA K; NOMURA T; MOMOI T; TSUCHIYA H; KAMEYAMA T; YAMAGUCHI K;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT IMMUNOBIOL,13-1 TAKARAMACHI KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT EXPT THERAPEUT KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT MOL BIOL,CANC RES INST KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT ORTHOPAED SURG KANAZAWA ISHIKAWA 920 JAPAN NCNP,NATL INST NEUROSCI,DIV DEV & DIFFERENTIAT KODAIRA TOKYO 187 JAPAN
Titolo Testata:
Japanese Journal of Medical Science & Biology
fascicolo: 5-6, volume: 49, anno: 1996,
pagine: 209 - 218
SICI:
0021-5112(1996)49:5-6<209:CDMICE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATIN STRUCTURE; DNA METHYLATION; ETHYL METHANESULFONATE; BURKITT-LYMPHOMA; CELLS; REPAIR; METHYLTRANSFERASE; PROTOONCOGENE; INDUCTION; ONCOGENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
G. Okada et al., "CARCINOGEN-INDUCED DE-NOVO METHYLATION IN C-MYC EXON-I", Japanese Journal of Medical Science & Biology, 49(5-6), 1996, pp. 209-218

Abstract

During the response of N-methyl-N-nitro-N-nitrosoguanidine (MNNG), methylation occurred at the Hpa II site of c-myc exon I, which is located downstream of the P1 initiation site, as evidenced by the assays of Hpa II-PCR. The Hpa II spite of the 5' flanking region did not undergomethylation. UV-irradiation also led to methylation in exon I. The extent of methylation increased depending on the dose of MNNG and UV. The results suggested that methylation takes place in transcriptionally active c-myc responsible for carcinogens and is caused by mechanisms different from that of alkylation in a specific CpG site. Possible contribution of methylation to less repair found in c-myc is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 06:47:43