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Titolo:
ABNORMAL EXPRESSION OF SEROTONIN TRANSPORTER MESSENGER-RNA IN THE FRONTAL AND TEMPORAL CORTEX OF SCHIZOPHRENICS
Autore:
HERNANDEZ I; SOKOLOV BP;
Indirizzi:
CUNY MT SINAI SCH MED,DEPT PSYCHIAT,BOX 1229,1 GUSTAVE L LEVY PL NEW YORK NY 10029 CUNY MT SINAI SCH MED,DEPT PSYCHIAT NEW YORK NY 10029
Titolo Testata:
Molecular psychiatry
fascicolo: 1, volume: 2, anno: 1997,
pagine: 57 - 64
SICI:
1359-4184(1997)2:1<57:AEOSTM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRITIATED IMIPRAMINE BINDING; CORTICAL DEVELOPMENT; RECEPTORS; SITES; LOBE; SUICIDES;
Keywords:
SCHIZOPHRENIA; POSTMORTEM BRAIN; SEROTONIN TRANSPORTER; MESSENGER-RNA EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
I. Hernandez e B.P. Sokolov, "ABNORMAL EXPRESSION OF SEROTONIN TRANSPORTER MESSENGER-RNA IN THE FRONTAL AND TEMPORAL CORTEX OF SCHIZOPHRENICS", Molecular psychiatry, 2(1), 1997, pp. 57-64

Abstract

Postmortem brain tissue was used to measure expression of serotonin transporter mRNA in the left frontal and left temporal cortex from schizophrenics (n = 24) and from normal control individuals with no history of psychiatric illness (n = 10). There was an approximately fourfoldincrease of serotonin transporter mRNA in Brodmann's area 9 and a two-fold decrease in Brodmann's areas 21 and 22. The changes in serotonintransporter mRNA were more prominent in schizophrenics who had received neuroleptic drugs within 1 week prior to death than in schizophrenics who were neuroleptic-free for more than 2 weeks prior to death, suggesting that the changes may be related to neuroleptic treatment. There was no correlation between serotonin transporter mRNA levels and thesex or age of schizophrenic and control cases or the postmortem delayintervals. These results support the hypothesis that region-specific changes in serotonin transporter expression occur in brains of some schizophrenics. Future studies are necessary to determine whether the changes in serotonin transporter expression are drug-related or are associated with the illness itself.

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Documento generato il 19/01/20 alle ore 09:15:37