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Titolo:
STUDIES OF THE POTENTIAL ROLE OF THE DOPAMINE D-1 RECEPTOR GENE IN ADDICTIVE BEHAVIORS
Autore:
COMINGS DE; GADE R; WU S; CHIU C; DIETZ G; MUHLEMAN D; SAUCIER G; FERRY L; ROSENTHAL RJ; LESIEUR HR; RUGLE LJ; MACMURRAY P;
Indirizzi:
CITY HOPE NATL MED CTR,DEPT MED GENET,1500 E DUARTE RD DUARTE CA 91010 CALIF STATE COLL SAN BERNARDINO,DEPT PSYCHOL SAN BERNARDINO CA 92407 LOMA LINDA UNIV,JERRY L PETTIS MEM VET HOSP LOMA LINDA CA 92357 UNIV CALIF LOS ANGELES,DEPT PSYCHIAT LOS ANGELES CA 90024 DEPT CRIMINAL JUSTICE SCI NORMAL IL 00000 DEPT VET AFFAIRS MED CTR,VET ADDICT RECOVERY CTR BRECKSVILLE OH 00000 LOMA LINDA UNIV,SCH MED,DEPT PSYCHIAT LOMA LINDA CA 00000
Titolo Testata:
Molecular psychiatry
fascicolo: 1, volume: 2, anno: 1997,
pagine: 44 - 56
SICI:
1359-4184(1997)2:1<44:SOTPRO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOURETTE-SYNDROME; ADHD PROBANDS; DRUG-ABUSE; ASSOCIATION; D1; SCHIZOPHRENIA; HOMOZYGOSITY; ALCOHOLISM; RELATIVES; COCAINE;
Keywords:
ALCOHOLISM; DRUG ABUSE; SMOKING; DOPAMINE; REWARD; TOURETTE SYNDROME; HETEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Comings et al., "STUDIES OF THE POTENTIAL ROLE OF THE DOPAMINE D-1 RECEPTOR GENE IN ADDICTIVE BEHAVIORS", Molecular psychiatry, 2(1), 1997, pp. 44-56

Abstract

Abnormalities in the dopaminergic reward pathways have frequently been implicated in substance abuse and addictive behaviors. Recent studies by Self and coworkers have suggested an important interaction between the dopamine D-1 and D-2 receptors in cocaine abuse. To test the hypothesis that the DRD1 gene might play a role in addictive behaviors weexamined the alleles of the Dde I polymorphism in three independent groups of subjects with varying types of compulsive, addictive behaviors - Tourette syndrome probands, smokers and pathological gamblers. In all three groups there was a significant increase in the frequency of homozygosity for the DRD1 Dde I 1 or 2 alleles in subjects with addictive behaviors. The DRD1 11 or 22 genotype was present in 41.3% of 63 controls and 57.3% of 227 TS probands (P = 0.024). When 23 quantitativetraits were examined by ANOVA those carrying the 11 genotype consistently had the highest scores. Based on these results, we examined the prevalence of the 11 genotype in controls, TS probands without a specific behavior, and TS probands with a specific behavior. There was a progressive, linear increase, significant at alpha less than or equal to 0.005 for scores for gambling, alcohol use and compulsive shopping. Problems with three additional behaviors, drug use, compulsive eating and smoking were significant at alpha less than or equal to 0.05. All six variables were related to addictive behaviors. In a totally separategroup of controls and individuals attending a smoking cessation clinic, and smoking at least one pack per day, 39.3% of the controls versus66.1% of the smokers carried the 11 or 22 genotype (P = 0.0002). In athird independent group of pathological gamblers, 55.3% carried the 11 or 22 genotype (P = 0.009 vs the combined controls). In the TS groupand smokers there was a significant additive effect of the DRD1 and DRD2 genes. The results for both the DRD1 and DRD2 genes, which have opposing effects on cyclic AMP, were consistent with negative and positive heterosis, respectively. These results support a role for genetic variants of the DRD1 gene in some addictive behaviors, and an interaction of genetic variants at the DRD1 and DRD2 genes.

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Documento generato il 04/12/20 alle ore 19:46:25