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Titolo:
VARIATION IN LIPOPROTEIN(A) CONCENTRATION ASSOCIATED WITH DIFFERENT APOLIPOPROTEIN(A) ALLELES
Autore:
PEROMBELON YFN; SOUTAR AK; KNIGHT BL;
Indirizzi:
HAMMERSMITH HOSP,MRC,LIPOPROT TEAM,DUCANE RD LONDON W12 0HS ENGLAND HAMMERSMITH HOSP,MRC,LIPOPROT TEAM LONDON W12 0HS ENGLAND
Titolo Testata:
The Journal of clinical investigation
fascicolo: 4, volume: 93, anno: 1994,
pagine: 1481 - 1492
SICI:
0021-9738(1994)93:4<1481:VILCAW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL HYPERCHOLESTEROLEMIA; RECEPTOR FUNCTION; PLASMA; GENE; HETEROGENEITY; PLASMINOGEN;
Keywords:
APOLIPOPROTEIN(A) GENOTYPING; APOLIPOPROTEIN(A) ISOFORMS; APOLIPOPROTEIN(A) PHENOTYPING; FAMILIAL HYPERCHOLESTEROLEMIA; FAMILIAL DEFECTIVE APOLIPOPROTEIN B-100;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
Y.F.N. Perombelon et al., "VARIATION IN LIPOPROTEIN(A) CONCENTRATION ASSOCIATED WITH DIFFERENT APOLIPOPROTEIN(A) ALLELES", The Journal of clinical investigation, 93(4), 1994, pp. 1481-1492

Abstract

Plasma lipoprotein(a) (Lp(a)) concentrations vary considerably between individuals. To examine the variation for products of the same and different apolipoprotein(a) (apo(a)) alleles, conditions were established whereby phenotyping immunoblots could be used to estimate the concentration of Lp(a) associated with the constituent apo(a) isoforms. In these studies 28 distinct isoforms were identified, each differing by a single kringle IV unit. Tracking the isoforms through 10 families showed that there could be up to 200-fold difference in the Lp(a) concentration associated with the same-sized isoform produced from differentalleles. In contrast there was typically < 2.5-fold variation in the Lp(a) concentration associated with the same allele. However, there were four occasions where the concentration associated with a particularallele was reduced below the typical range from one generation to thenext. A nonlinear, inverse trend with isoform size was apparently superimposed upon the other factors that determine Lp(a) concentration. Inheritance of familial hypercholesterolemia or familial-defective apoB(100) had little consistent effect upon Lp(a) concentration. In both the families and in other unrelated individuals the distribution of isoforms and their associated concentrations provided evidence for the presence of at least two and possibly more subpopulations of apo(a) alleles with different sizes and expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:16:28