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Titolo:
BRONCHIAL BIOPSY EVIDENCE FOR LEUKOCYTE INFILTRATION AND UP-REGULATION OF LEUKOCYTE-ENDOTHELIAL CELL-ADHESION MOLECULES 6 HOURS AFTER LOCALALLERGEN CHALLENGE OF SENSITIZED ASTHMATIC AIRWAYS
Autore:
MONTEFORT S; GRATZIOU C; GOULDING D; POLOSA R; HASKARD DO; HOWARTH PH; HOLGATE ST; CARROLL MP;
Indirizzi:
UNIV MED SOUTHAMPTON,SOUTHMEAD GEN HOSP,DEPT IMMUNOPHARMACOL,LEVEL D,CTR BLOCK,TREMONA RD SOUTHAMPTON SO9 4XY HANTS ENGLAND UNIV MED SOUTHAMPTON,SOUTHMEAD GEN HOSP,DEPT IMMUNOPHARMACOL SOUTHAMPTON SO9 4XY HANTS ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED LONDON W1Z ONN ENGLAND
Titolo Testata:
The Journal of clinical investigation
fascicolo: 4, volume: 93, anno: 1994,
pagine: 1411 - 1421
SICI:
0021-9738(1994)93:4<1411:BBEFLI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-INDUCED ACUTE; HUMAN MAST-CELLS; BRONCHOALVEOLAR LAVAGE; CHEMOTACTIC ACTIVITY; PERIPHERAL AIRWAYS; CROSS-LINKAGE; FC-EPSILON; T-CELLS; PROVOCATION; EOSINOPHILS;
Keywords:
ALLERGEN; ASTHMA; LEUKOCYTES; ADHESION MOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
S. Montefort et al., "BRONCHIAL BIOPSY EVIDENCE FOR LEUKOCYTE INFILTRATION AND UP-REGULATION OF LEUKOCYTE-ENDOTHELIAL CELL-ADHESION MOLECULES 6 HOURS AFTER LOCALALLERGEN CHALLENGE OF SENSITIZED ASTHMATIC AIRWAYS", The Journal of clinical investigation, 93(4), 1994, pp. 1411-1421

Abstract

We have examined the mucosal changes occurring in bronchial biopsies from six atopic asthmatics 5-6 h after local endobronchial allergen challenge and compared them with biopsies from saline-challenged segments from the same subjects at the same time point. All the subjects developed localized bronchoconstriction in the allergen-challenged segmentand had a decrease in forced expiratory volume in 1 s (FEV(1)) (P < 0.01) and a decrease in their methacholine provocative concentration ofagonist required to reduce FEV(1) from baseline by 20% (P < 0.05) 24 h postchallenge. At 6 h we observed an increase in neutrophils (P = 0.03), eosinophils (P = 0.025), mast cells (P = 0.03), and CD3(+) lymphocytes (P = 0.025), but not in CD4(+) or CD8(+) lymphocyte counts. We also detected an increase in endothelial intercellular adhesion molecule type 1 (P < 0.05) and E-selectin (P < 0.005), but not vascular cell adhesion molecule type 1 expression with a correlative increase in submucosal and epithelial LFA(+) leucocytes (P < 0.01). Thus, in sensitized asthmatics, local endobronchial allergen instillation leads to an increased inflammatory cell infiltrate of the airway mucosa that involves upregulation of specific adhesion molecules expressed on the microvasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:08:47