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Titolo:
ENDOPLASMIC-RETICULUM SIGNAL SEQUENCE FACILITATED TRANSPORT OF PEPTIDE EPITOPES RESTORES IMMUNOGENICITY OF AN ANTIGEN-PROCESSING DEFECTIVE TUMOR-CELL LINE
Autore:
KHANNA R; BURROWS SR; ARGAET V; MOSS DJ;
Indirizzi:
QUEENSLAND INST MED RES,BANCROFT CTR,300 HERSTON RD BRISBANE QLD 4029AUSTRALIA
Titolo Testata:
International immunology
fascicolo: 4, volume: 6, anno: 1994,
pagine: 639 - 645
SICI:
0953-8178(1994)6:4<639:ESSFTO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE-T EPITOPE; CLASS-II REGION; EXPRESSION; MOLECULES; VECTOR; GENE; MHC;
Keywords:
BURKITTS LYMPHOMA; CTL EPITOPE; CYTOTOXIC T LYMPHOCYTES; EPSTEIN - BARR VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R. Khanna et al., "ENDOPLASMIC-RETICULUM SIGNAL SEQUENCE FACILITATED TRANSPORT OF PEPTIDE EPITOPES RESTORES IMMUNOGENICITY OF AN ANTIGEN-PROCESSING DEFECTIVE TUMOR-CELL LINE", International immunology, 6(4), 1994, pp. 639-645

Abstract

The identification of MHC-restricted and tumour-specific cytotoxic T lymphocytes (CTLs) provides strong evidence in support of T cell-mediated immune surveillance against human tumour cells. These CTLs recognize short peptides derived from tumour-associated antigens in conjunction with class I molecules expressed on tumour cells. In contrast to these observations there are now numerous examples to suggest that a number of tumours escape this CTL-mediated control either by down-regulating accessory molecules or by blocking the intracellular processing oftumour-specific antigens. Recently a number of tumour cell lines havebeen identified which display a transcriptional deficiency of transporters associated with antigen processing (also referred to as TAP). The Epstein - Barr virus (EBV)-associated tumour, Burkitt's lymphoma (BL), is a classic example in this category. In the present study we haverestored class I-restricted antigen processing in a st. cell line by transfecting a minigene expression Vector encoding a CTL epitope derived from EBV linked to an endoplasmic reticulum translocation signal sequence. These minigene transfected BL cells were not only susceptible to lysis by virus-specific CTL but were also capable of efficiently activating an antigen-specific CTL response. Interestingly, the immunogenicity of these BL cells was not affected by the significantly down-regulated expression of adhesion molecules such as LFA1 alpha, LFA1 betaand LFA3. These findings suggest that resistance of tumour cells to CTL-mediated immune control can be reversed if the relevant peptide epitopes are appropriately presented on the cell surface.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:03:40