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Titolo:
NUCLEOTIDE-FREE DIET IMPAIRS T-HELPER CELL FUNCTIONS IN ANTIBODY-PRODUCTION IN RESPONSE TO T-DEPENDENT ANTIGENS IN NORMAL C57BL 6 MICE/
Autore:
JYONOUCHI H; ZHANGSHANBHAG L; TOMITA Y; YOKOYAMA H;
Indirizzi:
UNIV MINNESOTA,DEPT PEDIAT,DIV IMMUNOL MINNEAPOLIS MN 55455 MIYAZAKI UNIV,DEPT ANIM NUTR MIYAZAKI 88921 JAPAN OTSUKA PHARMACEUT FACTORY,NUTR RES LAB TOKUSHIMA 772 JAPAN
Titolo Testata:
The Journal of nutrition
fascicolo: 4, volume: 124, anno: 1994,
pagine: 475 - 484
SICI:
0022-3166(1994)124:4<475:NDITCF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECRETING CELLS; IMMUNE FUNCTION; ENUMERATION;
Keywords:
NUCLEOTIDES; T-HELPER CELLS; T-DEPENDENT ANTIGEN; MICE; T-INDEPENDENT ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H. Jyonouchi et al., "NUCLEOTIDE-FREE DIET IMPAIRS T-HELPER CELL FUNCTIONS IN ANTIBODY-PRODUCTION IN RESPONSE TO T-DEPENDENT ANTIGENS IN NORMAL C57BL 6 MICE/", The Journal of nutrition, 124(4), 1994, pp. 475-484

Abstract

We have previously shown that poly-nucleotides enhance in vitro antibody production in response to T-dependent antigens. This study examines the importance of dietary nucleotides on in vivo antibody productionin response to antigen stimuli. C57Bl/6 mice fed a nucleotide-free diet for more than 3 wk demonstrated significantly lower antibody production to T-dependent antigens both in vivo and in vitro compared with control mice fed a nonpurified diet. Numbers of immunoglobulin M and G secreting cells in the spleen were also lower in mice fed a nucleotide-free diet after the challenge of T-dependent antigens compared to thecontrols. Responses to T-independent antigens remained intact in micefed a nucleotide-free diet. T-helper cells from mice fed a nucleotide-free diet were less capable of inducing T-dependent antibody production in vitro compared with those from mice fed a nonpurified diet. Intraperitoneal injection of a mononucleotide-nucleoside mixture restored T-helper cell functions and T-dependent antibody production in mice fed a nucleotide-free diet. These results may indicate the importance ofdietary nucleotides in maintaining optimal T-helper cell functions for humoral immune responses in response to T-dependent antigens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:48:50