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Titolo:
THE SYNTHESIS OF [10-C-13]BILIRUBIN-IX-ALPHA
Autore:
STURROCK ED; BULL JR; KIRSCH RE;
Indirizzi:
UNIV CAPE TOWN,MRC,LIVER RES CTR CAPE TOWN 7925 SOUTH AFRICA UNIV CAPE TOWN,DEPT CHEM CAPE TOWN 7925 SOUTH AFRICA
Titolo Testata:
Journal of labelled compounds & radiopharmaceuticals
fascicolo: 3, volume: 34, anno: 1994,
pagine: 263 - 274
SICI:
0362-4803(1994)34:3<263:TSO[>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIRUBIN-IX; DIMETHYL ESTER; BILIVERDIN-IX; BILE-PIGMENTS; ISOMERS; DERIVATIVES; ALPHA;
Keywords:
[10-C-13]BILIRUBIN-IX-ALPHA; [10-C-13]BILIVERDIN-IX-ALPHA; C-13 LABELING; LABELED BILE PIGMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Sturrock et al., "THE SYNTHESIS OF [10-C-13]BILIRUBIN-IX-ALPHA", Journal of labelled compounds & radiopharmaceuticals, 34(3), 1994, pp. 263-274

Abstract

The total synthesis of [10-C-13]bilirubin IXalpha, the principal waste product of haem degradation, is described. Site specific labelling was accomplished by the Vilsmeier formylation of one of the dipyrrolic fragments using [1-C-13]dimethylformamide. The penultimate dehydrohalogenation reaction was complicated by a competing elimination reaction which yielded a bridged biliverdin derivative. [10-C-13]bilirubin IXalpha was prepared in an overall yield of 6 % (from the step where C-13 was introduced) with quantitative isotopic incorporation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:42:34