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Titolo:
EFFECT OF PKC INHIBITORS AND ACTIVATORS ON MEMORY
Autore:
ZHAO WQ; SEDMAN GL; GIBBS ME; NG KT;
Indirizzi:
LA TROBE UNIV BUNDOORA VIC 3083 AUSTRALIA LA TROBE UNIV BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Behavioural brain research
fascicolo: 2, volume: 60, anno: 1994,
pagine: 151 - 160
SICI:
0166-4328(1994)60:2<151:EOPIAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; LONG-TERM POTENTIATION; PHORBOL ESTER; NEUROTRANSMITTER RELEASE; SYNAPTIC PLASTICITY; SELECTIVE INCREASE; BRAIN NEURONS; POLYMYXIN-B; PHOSPHORYLATION; CALCIUM;
Keywords:
1-DAY-OLD CHICKEN; INTERMEDIATE MEMORY; PROTEIN KINASE C; PHORBOL ESTER; MELITTIN; PHORBOL 12-MYRISTATE 13-ACETATE; 4-ALPHA-PDD; 2,4-DINITROPHENOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
W.Q. Zhao et al., "EFFECT OF PKC INHIBITORS AND ACTIVATORS ON MEMORY", Behavioural brain research, 60(2), 1994, pp. 151-160

Abstract

Changes in the activity of the enzyme protein kinase C (PKC) have been implicated in learning and memory consolidation, and in the induction of long-term potentiation. The precise role of PKC in memory processing is still unknown. Using 1-day-old chicks trained on a single-trialpassive avoidance task, we demonstrate that inhibition of PKC activity by melittin induced retention loss, in a dose-dependent manner, in the second stage of a three-stage sequence of memory processing. The effect was lateralized to the left hemisphere of the chick forebrain. This effect of melittin was prevented by high concentrations (16-320 mu M) of the PKC activator, phorbol 12-myristate 13-acetate (PMA). Furthermore, concentrations of PMA in the range 1.6 to 40 mu M were shown toinduce long-term memory consolidation following a weakly reinforced version of the learning task, which normally does not lead to formationof longterm memory. That these actions of PMA are attributable to PKCactivation is supported by the further finding that the inactive phorbol ester 4 alpha-PDD had no effect either on melittin-induced amnesiaor on memory consolidation following weakly reinforced learning. Paradoxically, concentrations of 16 mu M or higher of PMA inhibited memoryconsolidation for the normal strongly reinforced learning trial, an effect again not observed with 40 alpha-PDD. The results are consistentwith the view that PKC activity may be implicated in a pre-long-term stage of memory processing.

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Documento generato il 04/08/20 alle ore 01:52:43