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Titolo:
CHANGES IN ONCOGENE EXPRESSION IN ASCITE TUMOR-CELLS DURING AGING
Autore:
BIAGETTI M; DELLAFAZIA MA; SERVILLO G; VIOLAMAGNI MP;
Indirizzi:
UNIV PERUGIA,INST GEN PATHOL I-06100 PERUGIA ITALY
Titolo Testata:
Cell proliferation
fascicolo: 4, volume: 27, anno: 1994,
pagine: 191 - 200
SICI:
0960-7722(1994)27:4<191:CIOEIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYC MESSENGER-RNA; C-MYC; GROWTH-FACTOR; MONOCLONAL-ANTIBODIES; HEMATOPOIETIC-CELLS; GENE-EXPRESSION; DOWN-REGULATION; PROTO-ONCOGENE; FLOW-CYTOMETRY; BREAST-CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Biagetti et al., "CHANGES IN ONCOGENE EXPRESSION IN ASCITE TUMOR-CELLS DURING AGING", Cell proliferation, 27(4), 1994, pp. 191-200

Abstract

The expression of two oncogenes, c-myc and c-fos, was studied in an ascitic tumour (ATPC+) at different times after implantation. The specific mRNA synthesis was analysed by Northern blot analysis. The presence of the oncogene proteins was shown by immunofluorescence using flow cytometry and referred to the distribution of the cells in the different cell phases. The results show that both oncogenes are expressed by ATPC+ tumour cells. c-myc is expressed 5, 8 and 12 days after implantation, although with a different intensity, and the protein is mainly present in S or S+G2 phase cells. The c-fos oncogene is expressed only 12 days after tumour implantation and the cells labelled with the specific antibody are mainly in G1 phase. We conclude that c-myc is principally correlated with proliferative activity, whereas c-fos is expressed by non-cycling cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 09:38:56