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Titolo:
A HIGHLY REGIOSELECTIVE ESTERASE FROM PENICILLIUM-FREQUENTANS IMI-92265
Autore:
WORONIECKI SR; ARMITAGE PA; ELSON SW; FORD BD; SIME JT;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,BROCKHAM PK BETCHWORTH RH3 7AJ SURREY ENGLAND SMITHKLINE BEECHAM PHARMACEUT,BROCKHAM PK BETCHWORTH RH3 7AJ SURREY ENGLAND
Titolo Testata:
Biocatalysis
fascicolo: 4, volume: 8, anno: 1994,
pagine: 309 - 320
SICI:
0886-4454(1994)8:4<309:AHREFP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPASE;
Keywords:
REGIOSELECTIVITY; ACETYLESTERASE; IMMOBILIZED ENZYME; ESTER HYDROLYSIS; PENICILLIUM-FREQUENTANS IMI-92265; 4-ACETOXY-3-ACETOXYMETHYLBUTAN-1-OL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S.R. Woroniecki et al., "A HIGHLY REGIOSELECTIVE ESTERASE FROM PENICILLIUM-FREQUENTANS IMI-92265", Biocatalysis, 8(4), 1994, pp. 309-320

Abstract

An esterase isolated from Penicillium frequentans IMI 92265 selectively hydrolyses the acetoxyethyl ester in preference to the acetoxymethyl esters in the triacetate substrate 1,4-diacetoxy-2-acetoxymethylbutane (1) which was converted to 4-acetoxy-3-acetoxymethylbutan-1-ol (2) in good yield. The enzyme gave no detectable hydrolysis of 1,3-diacetoxy-2-acetoxymethylpropane (4). When immobilised to a cyanogen bromide activated Sepharose resin the enzyme was highly stable and showed no loss of regioselectivity in the hydrolysis of (1). A method is described for the elective isolation of microorganisms which have the ability to hydrolyse (1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:06:50