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Titolo:
MORPHOLOGY, ELECTROPHYSIOLOGY AND PATHOPHYSIOLOGY OF SUPRAGRANULAR NEURONS IN RAT PRIMARY SOMATOSENSORY CORTEX
Autore:
SCHRODER R; LUHMANN HJ;
Indirizzi:
UNIV DUSSELDORF,INST NEUROPHYSIOL,POB 101007 D-40001 DUSSELDORF GERMANY UNIV DUSSELDORF,INST NEUROPHYSIOL D-40001 DUSSELDORF GERMANY
Titolo Testata:
European journal of neuroscience
fascicolo: 1, volume: 9, anno: 1997,
pagine: 163 - 176
SICI:
0953-816X(1997)9:1<163:MEAPOS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORY POSTSYNAPTIC POTENTIALS; CAT VISUAL-CORTEX; PYRAMIDAL NEURONS; NEOCORTICAL NEURONS; DENDRITIC MORPHOLOGY; FRONTAL-CORTEX; STRIATE CORTEX; CELLS; INVITRO; PROJECTIONS;
Keywords:
BRAIN SLICES; CORTICAL CIRCUITRY; HYPOXIA; INTRACELLULAR LABELING; MORPHOMETRIC ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
R. Schroder e H.J. Luhmann, "MORPHOLOGY, ELECTROPHYSIOLOGY AND PATHOPHYSIOLOGY OF SUPRAGRANULAR NEURONS IN RAT PRIMARY SOMATOSENSORY CORTEX", European journal of neuroscience, 9(1), 1997, pp. 163-176

Abstract

Intracellularly biocytin-labelled neurons in layers II/III of adult rat primary somatosensory cortex were analysed for their morphological and electrophysiological properties and studied for their response pattern to transient hypoxia under in vitro conditions. The largest dendritic region is formed by the basal dendrites, which constitute an average area of 0.06 mm(2) and which can receive synaptic inputs over horizontal distances of more than 300 mu m. The dendritic territories formed by the oblique dendrites situated on the apical trunk and by the apical tuft are much smaller. The spine density is highest on the apicaltrunk, suggesting that large numbers of excitatory synapses are present in this region of the cell. All neurons revealed intrinsic membraneproperties of typical regular spiking cells and received an excitatory and a strong biphasic inhibitory input. Whereas a significant correlation could be detected between the cell's input resistance and soma area, no correlation existed between the cell's total dendritic length and input resistance or membrane time constant/input resistance. Neurons responded to transient hypoxia either with an anoxic hyperpolarization with an apparent reversal potential of -82.4 mV, or with a gradualanoxic depolarization which reversed at -56 mV. Oxygen deprivation caused a significant reduction in the extent of axonal collaterals, whereas dendritic proportions and spine density were unaffected. The present study indicates that the dendritic tree is well preserved under in vitro conditions, whereas axonal connections are diminished by oxygen deprivation, Our results further suggest that certain structural properties correlate with the cellular physiology, but that the cell's morphology does not determine its responsiveness to hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:49:52