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Titolo:
PAROMOMYCIN - AN EFFECTIVE TREATMENT FOR CRYPTOSPORIDIAL DIARRHEA IN PATIENTS WITH AIDS
Autore:
BISSUEL F; COTTE L; RABODONIRINA M; ROUGIER P; PIENS MA; TREPO C;
Indirizzi:
HOP HOTEL DIEU,AIDS & HEPATOGASTROENTEROL UNIT,1 PL HOP F-69288 LYON 02 FRANCE UNIV LYON 1,PARASITOL LAB LYON FRANCE INSERM,UNITE 271,AIDS & HEPATITIS RES UNIT LYON FRANCE
Titolo Testata:
Clinical infectious diseases
fascicolo: 3, volume: 18, anno: 1994,
pagine: 447 - 449
SICI:
1058-4838(1994)18:3<447:P-AETF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
F. Bissuel et al., "PAROMOMYCIN - AN EFFECTIVE TREATMENT FOR CRYPTOSPORIDIAL DIARRHEA IN PATIENTS WITH AIDS", Clinical infectious diseases, 18(3), 1994, pp. 447-449

Abstract

Cryptosporidiosis is a common cause of diarrhea in patients with AIDSbut remains one of the most challenging AIDS-related conditions to treat. We therefore carried out an open, uncontrolled, prospective studyto evaluate the efficacy of oral paromomycin for the treatment of chronic diarrhea due to Cryptosporidium in 24 successive patients infected with human immunodeficiency virus. Twenty-two of the 24 patients responded clinically, with complete remission occurring in 18 cases and marked reduction of the diarrhea occurring in four. Clearance of cryptosporidia from stools and/or intestinal biopsy specimens occurred within 2-4 weeks. Furthermore, all 18 patients who achieved complete remission gained weight. Ten patients relapsed either during administration of maintenance therapy or after discontinuation of treatment, but diarrhea resolved again after increasing or restarting paromomycin therapyin all but two. Paromomycin appeared to be an active and well-tolerated treatment for cryptosporidiosis in patients with AIDS. Efficacy is dose-related, and continuous maintenance therapy is required to prevent relapses. These data suggest that paromomycin might be given as first-line therapy in AIDS-related cryptosporidiosis, but this should be confirmed by the findings of a controlled, randomized trial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:58:12