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Titolo:
INCREASE IN INSULIN-LIKE GROWTH-FACTOR-I IN HYPERTROPHYING SMOOTH-MUSCLE
Autore:
CHEN Y; BORNFELDT KE; ARNER A; JENNISCHE E; MALMQVIST U; UVELIUS B; ARNQVIST HJ;
Indirizzi:
LINKOPING UNIV,FAC HLTH SCI,DEPT PHARMACOL S-58185 LINKOPING SWEDEN LINKOPING UNIV,FAC HLTH SCI,DEPT MED S-58185 LINKOPING SWEDEN GOTHENBURG UNIV,DEPT HISTOL S-40033 GOTHENBURG SWEDEN LUND UNIV,DEPT PHYSIOL & BIOPHYS S-22007 LUND SWEDEN LUND UNIV,DEPT UROL S-22007 LUND SWEDEN
Titolo Testata:
The American journal of physiology
fascicolo: 2, volume: 266, anno: 1994,
parte:, 1
pagine: 50000224 - 50000229
SICI:
0002-9513(1994)266:2<50000224:IIIGIH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; BINDING-PROTEIN; CYTOSKELETAL PROTEINS; IGF-I; CELLS; SEQUENCE; PROLIFERATION; HYBRIDIZATION; BIOSYNTHESIS; HYPERTENSION;
Keywords:
IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR I RECEPTOR; GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Y. Chen et al., "INCREASE IN INSULIN-LIKE GROWTH-FACTOR-I IN HYPERTROPHYING SMOOTH-MUSCLE", The American journal of physiology, 266(2), 1994, pp. 50000224-50000229

Abstract

The present study focuses on the role of the insulinlike growth factor (IGF) system in the development of smooth muscle hypertrophy. Hypertrophy was initiated by partial ligation of portal vein or urethra in female Sprague-Dawley rats weighing similar to 220 g. Levels of mRNA were analyzed by solution hybridization. Seven days after ligation, the wet weight of the portal vein was increased about threefold and the concentration of IGF-I mRNA was increased fourfold. The bladder wet weight was increased twofold 3 days after ligation and fourfold 10 days after ligation. IGF-I mRNA in the bladder was elevated S-fold after 3 days and 2.5-fold after 10 days, whereas IGF binding protein 2 mRNA was increased similar to 2-fold after 3 days and 5-fold after 10 days. IGF-I receptor mRNA in the hypertrophying bladder remained unchanged. Increased levels of IGF-I were demonstrated with immunohistochemistry in both hypertrophying portal vein and urinary bladder. The results show a specific increase in IGF-I mRNA as well as an increased IGF-I immunoreactivity during hypertrophy of smooth muscle, which suggests that the local IGF-system may play a role in smooth muscle hypertrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:45:55