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Titolo:
ALDOSTERONE SELECTIVELY INCREASES NA-K+-ATPASE ALPHA(3)-SUBUNIT MESSENGER-RNA EXPRESSION IN RAT HIPPOCAMPUS()
Autore:
FARMAN N; BONVALET JP; SECKL JR;
Indirizzi:
UER XAVIER BICHAT,INSERM,U246,16 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE UNIV EDINBURGH,WESTERN GEN HOSP,DEPT MED EDINBURGH EH4 2XU SCOTLAND
Titolo Testata:
The American journal of physiology
fascicolo: 2, volume: 266, anno: 1994,
parte:, 1
pagine: 30000423 - 30000428
SICI:
0002-9513(1994)266:2<30000423:ASINAM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NA+,K+-ATPASE ALPHA-SUBUNIT; MINERALOCORTICOID RECEPTOR; MESSENGER-RNAS; INSITU HYBRIDIZATION; 5'-FLANKING REGION; CATALYTIC SUBUNIT; GENE-EXPRESSION; SODIUM-PUMP; NA,K-ATPASE;
Keywords:
DEXAMETHASONE; BRAIN ALPHA(1), ALPHA(2); SODIUM-POTASSIUM-ADENOSINE-TRIPHOSPHATASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
N. Farman et al., "ALDOSTERONE SELECTIVELY INCREASES NA-K+-ATPASE ALPHA(3)-SUBUNIT MESSENGER-RNA EXPRESSION IN RAT HIPPOCAMPUS()", The American journal of physiology, 266(2), 1994, pp. 30000423-30000428

Abstract

In the brain, corticosteroids bind to intracellular glucocorticoid (GR) and mineralocorticoid (MR) receptors, affecting target gene transcription, and thereby altering neuronal function, including electrophysiological activity. The hippocampus very highly expresses both MR and GR; however, MR-regulated hippocampal transcripts have not yet been described. We investigated the effects of adrenalectomy +/- glucocorticoid or mineralocorticoid replacement on expression of mRNAs encoding alpha-subunit isoforms of Na+-K+-adenosinetriphosphatase, a critical transmembrane ion gradient-regulating enzyme. Aldosterone significantly increased alpha(3)-subunit mRNA expression in dentate gyrus granule cells (62% increase compared with adrenalectomy) and in CA(1) and CA(4) hippocampal neurons (37 and 38%), but not in CA(2), CA(3), parietal cortex neurons, or glia. This effect was not reproduced by dexamethasone, and none of the corticosteroid manipulations altered alpha(1)- or alpha(2)-subunit mRNA expression at any site examined. Aldosterone-mediated upregulation of hippocampal aa-subunit mRNA expression may underlie,at least in part, the specific actions of MR ligands on hippocampal function. The observation that aldosterone differentially affects alpha(3)-isoform mRNA expression in distinct neuronal populations, associated with the established aldosterone modulations of alpha(1)-isoform mRNA in epithelial cells, supports the presence of cell-specific factorsthat regulate MR-mediated transcriptional activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:33:08