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Titolo:
WEIGHT-LOSS IN RATS FOLLOWING INTRAVENTRICULAR TRANSPLANTS OF PANCREATIC-ISLETS
Autore:
RICHARDSON RD; RAMSAY DS; LERNMARK A; SCHEURINK AJW; BASKIN DG; WOODS SC;
Indirizzi:
UNIV WASHINGTON,DEPT PSYCHOL,NI25 SEATTLE WA 98195 UNIV WASHINGTON,DEPT ORTHODONT SEATTLE WA 98195 UNIV WASHINGTON,DEPT PEDIAT DENT SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOL STRUCT SEATTLE WA 98195 SEATTLE VET AFFAIRS MED CTR SEATTLE WA 98108
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 266, anno: 1994,
parte:, 2
pagine: 180000059 - 180000064
SICI:
0002-9513(1994)266:1<180000059:WIRFIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
REDUCES FOOD-INTAKE; CHRONIC INTRACEREBROVENTRICULAR INFUSION; INSULIN-BINDING-SITES; OBESE ZUCKER RATS; BODY-WEIGHT; CEREBROSPINAL-FLUID; BRAIN;
Keywords:
BRAIN INSULIN; INSULIN; FOOD INTAKE; TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Richardson et al., "WEIGHT-LOSS IN RATS FOLLOWING INTRAVENTRICULAR TRANSPLANTS OF PANCREATIC-ISLETS", The American journal of physiology, 266(1), 1994, pp. 180000059-180000064

Abstract

Because of the body's resistance to permanent weight change, obesity remains a major health problem in modern society. It is hypothesized that the regulatory system defending body weight utilizes pancreatic insulin as an indicator of adiposity to the brain. To take advantage of this negative feedback system, we transplanted neonatal (experiment 1)or adult (experiment 2) pancreatic islets containing insulin-secreting cells into the 3rd ventricle of syngeneic Lewis rats. This resulted in an elevation of the insulin signal within the brain and a significant long-term reduction of body weight. Changes in food intake were consistent with the changes of body weight. The implantation of more islets resulted in a greater reduction of body weight, and changes in weight were inversely correlated with the level of insulin achieved in thecerebrospinal fluid. After the two studies were completed, histological examination revealed the presence of insulin-containing cells within the 3rd ventricle and adjacent hypothalamus. These studies suggest that transplanted insulin-secreting cells may provide a potential therapeutic strategy for maintenance of weight loss.

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Documento generato il 15/07/20 alle ore 07:44:21