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Titolo:
REFLEX REGULATION OF RENAL NERVE ACTIVITY IN CARDIAC-FAILURE
Autore:
DIBONA GF; SAWIN LL;
Indirizzi:
UNIV IOWA,COLL MED,DEPT INTERNAL MED IOWA CITY IA 52242 VET AFFAIRS MED CTR IOWA CITY IA 52242
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 266, anno: 1994,
parte:, 2
pagine: 180000027 - 180000039
SICI:
0002-9513(1994)266:1<180000027:RRORNA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; CHRONIC VOLUME OVERLOAD; BARORECEPTOR SENSITIVITY; DOGS; RATS; NATRIURESIS;
Keywords:
CONGESTIVE HEART FAILURE; ARTERIAL BARORECEPTORS; CARDIAC BARORECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G.F. Dibona e L.L. Sawin, "REFLEX REGULATION OF RENAL NERVE ACTIVITY IN CARDIAC-FAILURE", The American journal of physiology, 266(1), 1994, pp. 180000027-180000039

Abstract

Efferent renal sympathetic nerve activity (ERSNA) is increased in therat with low-cardiac-output congestive heart failure (CHF; myocardialinfarction). Arterial and cardiopulmonary baroreflex control of ERSNAin CHF and control rats was examined. Cardiac index and arterial pressure were lower and total peripheral resistance index, left ventricular end-diastolic pressure, and heart-to-body weight ratio were higher in CHF than in control rats. Increases in left ventricular end diastolic pressure produced by intravenous volume loading failed to increase cardiac index in CHF rats as it did in control rats. Single-unit analysis of aortic baroreceptor nerve activity showed that CHF rats had higher pressure threshold, lower frequency at pressure threshold, and lower gain than control rats. Arterial baroreflex control of ERSNA was attenuated; this was due to diminished gain of the afferent limb while the gain of the central portion of the reflex was normal. Single-unit analysis of vagal nerve activity showed that CHF rats had higher pressure threshold, lower frequency at saturation, and lower gain than control rats. Cardiopulmonary baroreflex control of ERSNA was attenuated; this was due to diminished gain of the afferent limb while the gain of the central portion of the reflex was normal. In the CHF rat, arterial and cardiopulmonary baroreflex control of ERSNA is markedly attenuatedbecause of abnormalities in the periphery at the level of the aortic and cardiopulmonary receptors, respectively, and not in the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:59:38