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Titolo:
AIDS, ALCOHOL, ENDOTHELIUM, AND IMMUNITY
Autore:
WITTE MH; BORGS P; WAY DL; RAMIREZ G; WITTE CL; BERNAS MJ;
Indirizzi:
UNIV ARIZONA,COLL MED,DEPT SURG,1501 N CAMPBELL AVE TUCSON AZ 85724
Titolo Testata:
Alcohol
fascicolo: 2, volume: 11, anno: 1994,
pagine: 91 - 97
SICI:
0741-8329(1994)11:2<91:AAEAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER; CELLS; INFECTION; ETHANOL; DAMAGE; RATS;
Keywords:
ALCOHOL; ENDOTHELIUM; IMMUNITY; HIV; ANGIOGENESIS; KAPOSIS SARCOMA; COFACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Witte et al., "AIDS, ALCOHOL, ENDOTHELIUM, AND IMMUNITY", Alcohol, 11(2), 1994, pp. 91-97

Abstract

Analogies are drawn between important unknowns in AIDS and alcohol research, related to underlying common pathogenetic mechanisms, immunodysregulation, cofactors, and prominent vascular manifestations. The central role of the blood and lymphatic vasculatures and specifically their endothelial lining in many facets of the immune response is reviewed. Evidence is presented that both alcohol and HIV (as well as other coinfecting viruses in AIDS) target and alter endothelial cells and theangiogenic process. These concepts are further illustrated by a serendipitous viral epidemic among rats on continuous long-term alcoholic and control nonalcoholic diets, where synergism between alcohol and virus appeared to underlie multiple vascular proliferative lesions in theliver. In AIDS and alcoholism/alcoholic liver disease (ALD), the prominent features of dysregulated angiogenesis point to the endothelium as a key player in pathogenesis of these seemingly disparate disorders and potentially in immunomodulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:33:41