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Titolo:
RAPID DETECTION OF TRANSLATION-TERMINATING MUTATIONS AT THE ADENOMATOUS POLYPOSIS-COLI (APC) GENE BY DIRECT PROTEIN TRUNCATION TEST
Autore:
VANDERLUIJT R; KHAN PM; VASEN H; VANLEEUWEN C; TOPS C; ROEST P; DENDUNNEN J; FODDE R;
Indirizzi:
LEIDEN UNIV,SYLVIUS LAB,DEPT HUMAN GENET,MGC,POB 9503 2300 RA LEIDEN NETHERLANDS
Titolo Testata:
Genomics
fascicolo: 1, volume: 20, anno: 1994,
pagine: 1 - 4
SICI:
0888-7543(1994)20:1<1:RDOTMA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-LINE MUTATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
R. Vanderluijt et al., "RAPID DETECTION OF TRANSLATION-TERMINATING MUTATIONS AT THE ADENOMATOUS POLYPOSIS-COLI (APC) GENE BY DIRECT PROTEIN TRUNCATION TEST", Genomics, 20(1), 1994, pp. 1-4

Abstract

Familial adenomatous polyposis (FAP) is usually associated with protein truncating mutations in the adenomatous polyposis coli (APC) gene. The APC mutations are known to play a major role in colorectal carcinogenesis. For the identification of protein truncating mutations of theAPC gene, we developed a rapid, sensitive, amen direct screening procedure. The technique is based on the in vitro transcription and translation of the genomic PCR products and is called the protein truncationtest. Samples of DNA from individual FAP patients,members of a FAP family, colorectal tumors, and colorectal tumor-derived cell lines were used to show the effectiveness of this method. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:18:03