Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
USE OF AN ALLOGENEIC ANTIGEN TO INDUCE RESISTANCE AND REGRESSION OF AN AUTOLOGOUS TUMOR
Autore:
HIRAMOTO RN; GHANTA VK; SOONG SJ; HIRAMOTO NS;
Indirizzi:
UNIV ALABAMA,DEPT MICROBIOL,UAB STN BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT BIOL BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT BIOSTAT BIRMINGHAM AL 35294
Titolo Testata:
Journal of immunotherapy with emphasis on tumor immunology
fascicolo: 3, volume: 15, anno: 1994,
pagine: 202 - 211
SICI:
1067-5582(1994)15:3<202:UOAAAT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADOPTIVE IMMUNOTHERAPY; POLYETHYLENE-GLYCOL; CYTO-TOXICITY; SPLEEN-CELLS; T-CELLS; CANCER; MICE; CYTOTOXICITY; ERADICATION; ENHANCEMENT;
Keywords:
CHEMOIMMUNOTHERAPY; TREATMENT OF AUTOLOGOUS TUMOR; AUTOIMMUNOTHERAPY; MULTIMODALITY THERAPY; ALLOGENEIC ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Hiramoto et al., "USE OF AN ALLOGENEIC ANTIGEN TO INDUCE RESISTANCE AND REGRESSION OF AN AUTOLOGOUS TUMOR", Journal of immunotherapy with emphasis on tumor immunology, 15(3), 1994, pp. 202-211

Abstract

Studies were initiated to determine if it was possible to use a tumor-bearing animal's own spleen cells to impart resistance to its neoplasm. YC8 T-cell lymphoma-bearing BALB/c mice (TBAs) were immunized with allogeneic DBA/2 spleen cells, which share cross-reacting antigens with the YC8 tumor. Animals immunized with the alloantigen were splenectomized and their spleen cells co-cultured with additional alloantigens for 2 days in media containing 2% polyethylene glycol (PEG) before being returned to the cyclophosphamide (cytoxan) (Ctx) pretreated autologous host. Treatment with Ctx was used to reduce suppressor factors in the TBA. It was found that when cultured spleen cells were returned tothe autologous TBA, much greater resistance was imparted to the host and, in many instances, regression of the YC8 tumor was observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:56:23