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Titolo:
HORMONAL AGENTS USED IN LOWERING LIPOPROTEIN(A)
Autore:
SOMA MR; MESCHIA M; BRUSCHI F; MORRISETT JD; PAOLETTI R; FUMAGALLI R; CROSIGNANI PG;
Indirizzi:
UNIV MILAN,INST PHARMACOL SCI,VIA BALZARETTI 9 I-20133 MILAN ITALY UNIV MILAN,DEPT OBSTET & GYNAECOL I-20100 MILAN ITALY BAYLOR COLL MED,METHODIST HOSP HOUSTON TX 77030
Titolo Testata:
Chemistry and physics of lipids
, volume: 67-8, anno: 1994,
pagine: 345 - 350
SICI:
0009-3084(1994)67-8:<345:HAUILL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-DISEASE; LP(A) LIPOPROTEIN; RISK-FACTORS; ESTROGEN; THERAPY;
Keywords:
LP(A); GENDER; SEX HORMONES; HORMONE REPLACEMENT THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Soma et al., "HORMONAL AGENTS USED IN LOWERING LIPOPROTEIN(A)", Chemistry and physics of lipids, 67-8, 1994, pp. 345-350

Abstract

Lipoprotein(a) (Lp(a)) plasma concentrations in Caucasian populationsare classified as a quantitative genetic trait. Although the prevailing view has been that Lp(a) levels are affected by age and gender, recent data are beginning to indicate otherwise. Lp(a) levels change throughout life especially in females after menopause. Lp(a) levels decrease in women treated with anabolic steroids such as stanozolol and danazol. The Lp(a) plasma concentration is also profoundly affected by sexhormone variations during pregnancy. In men with prostatic cancer Lp(a) levels are reduced about 50% by estrogen therapy, and increased 20%by orchidectomy. We have evaluated the changes in Lp(a) and lipid levels in postmenopausal women following estrogen/progestogen replacementtherapy. The mean level of Lp(a) in treated women was about 50% lowerafter 6 and 12 months of replacement therapy. A significant correlation between basal Lp(a) levels and the changes at either 6 or 12 monthswas observed, suggesting that therapy was particularly efficacious inthose women with high basal Lp(a) levels. One year after therapy cessation, Lp(a) concentrations tended to return to pre-therapy values. Inaddition estrogen-progestogen treatment significantly lowered total-cholesterol (12%) and LDL-cholesterol (28%), and increased HDL-cholesterol (18%). From these studies it appears that sex hormones are actively involved in the modulation of plasma Lp(a) levels and that both female and male sex hormones possess a lowering effect. The results confirm a direct effect of sex hormones on Lp(a) metabolism and suggest thatestrogen-progestogen treatment of postmenopausal women can improve the lipid profile not only by lowering total- and LDL-cholesterol and raising HDL cholesterol, but also by lowering plasma Lp(a).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 20:08:43