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Titolo:
LP(A) CATABOLISM IN HYPERCHOLESTEROLEMIC INDIVIDUALS
Autore:
KNIGHT BL;
Indirizzi:
HAMMERSMITH HOSP,MRC,LIPOPROT TEAM,DUCANE RD LONDON W12 0HS ENGLAND
Titolo Testata:
Chemistry and physics of lipids
, volume: 67-8, anno: 1994,
pagine: 233 - 239
SICI:
0009-3084(1994)67-8:<233:LCIHI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE; LIPOPROTEIN; MUTATION;
Keywords:
LP(A) CATABOLISM; LDL RECEPTORS; LP(A) IN FH AND FDB; LP(A) FAMILY STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Knight, "LP(A) CATABOLISM IN HYPERCHOLESTEROLEMIC INDIVIDUALS", Chemistry and physics of lipids, 67-8, 1994, pp. 233-239

Abstract

Three pieces of evidence are presented that suggest that LDL receptors are not greatly involved in the catabolism of intact Lp(a) in vivo. First, studies of normal and heterozygous familial hypercholesterolaemic (FH) siblings who have inherited identical apo(a) alleles have shown that the absence of effective LDL receptors is not invariably associated with an increase in the plasma concentration of Lp(a). Furthermore, in vitro competition studies with reduced Lp(a) from familial-defective apoB subjects indicate that their Lp(a), unlike their LDL, is notenriched with particles containing the binding-defective apoB. Finally, turnover studies in vivo showed no difference in catabolic rate forLp(a) between normal and FH subjects. There was, however, evidence tosuggest that LDL receptors could play a part in the ultimate clearance of Lp(a) by mediating the degradation of its lipid and apoB components after the removal of apo(a) in the circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:42:18