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Titolo:
EVIDENCE FOR AN INHIBITORY ROLE OF CENTRAL HISTAMINE ON CARRAGEENAN-INDUCED HYPERALGESIA
Autore:
NETTI C; SIBILIA V; GUIDOBONO F; VILLANI P; PECILE A; BRAGA PC;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL,VIA VANVITELLI 32 I-20129 MILAN ITALY
Titolo Testata:
Neuropharmacology
fascicolo: 2, volume: 33, anno: 1994,
pagine: 205 - 210
SICI:
0028-3908(1994)33:2<205:EFAIRO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADMINISTERED HISTAMINE; THALAMIC NEURONS; RAT; INFLAMMATION; PAIN; ANALGESIA;
Keywords:
HISTAMINE; H-1 RECEPTORS; H-2 RECEPTORS; CARAGEENIN; HYPERALGESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C. Netti et al., "EVIDENCE FOR AN INHIBITORY ROLE OF CENTRAL HISTAMINE ON CARRAGEENAN-INDUCED HYPERALGESIA", Neuropharmacology, 33(2), 1994, pp. 205-210

Abstract

The effects of intracerebroventricular (i.c.v.) injection of histamine, the H-1 agonist 2-methyl-histamine and the H-2 agonist dimaprit were tested on carrageenin induced hyperalgesia by the Randall-Selitto paw pressure test in the rat. Treatment with histamine (0.1, 0.2, 0.4 mumol/rat, i.c.v.) 150 min after intraplantar carrageenin (0.1 ml of 1%solution) caused a significant increase of paw pressure thresholds ininflamed (but not in non-inflamed) paws. The magnitude and the duration of the antinociceptive effects of histamine were dose-dependent. Administration of 2-methyl-histamine (0.2, 0.4, 0.8, 1.0 mu mol/rat, i.c.v.) and dimaprit (0.1, 0.2, 0.4, 0.8 mu mol/rat, i.c.v.) also displayed dose-dependent blockade of carrageenin-induced hyperalgesia. Antinociceptive ED(50) values calculated 30 min after drug treatments were: histamine 0.18 mu mol/rat; 2-methyl-histamine 0.65 mu mol/rat; dimaprit 0.33 mu mol/rat. These data indicate that histamine through central H-1 and H-2 receptors exerts an inhibitory role in the control of nociception in pain resulting from inflammation.

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Documento generato il 19/02/20 alle ore 21:01:35