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Titolo:
ESSENTIAL FATTY-ACID PREPARATION (SR-3) RAISES THE SEIZURE THRESHOLD IN RATS
Autore:
YEHUDA S; CARASSO RL; MOSTOFSKY DI;
Indirizzi:
BAR ILAN UNIV,DEPT PSYCHOL,PSYCHOPHARMACOL LAB IL-52900 RAMAT GAN ISRAEL HILLEL YAFFE HOSP,NEUROL UNIT HADERA ISRAEL BOSTON UNIV,DEPT PSYCHOL BOSTON MA 00000
Titolo Testata:
European journal of pharmacology
fascicolo: 1-2, volume: 254, anno: 1994,
pagine: 193 - 198
SICI:
0014-2999(1994)254:1-2<193:EFP(RT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; BRAIN; FOCI; IRON; CAT;
Keywords:
EPILEPSY, THERAPY; ALPHA-LINOLENIC ACID; LINOLEIC ACID; OMEGA-3/OMEGA-6 RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Yehuda et al., "ESSENTIAL FATTY-ACID PREPARATION (SR-3) RAISES THE SEIZURE THRESHOLD IN RATS", European journal of pharmacology, 254(1-2), 1994, pp. 193-198

Abstract

The anticonvulsant properties of a mixture of non-esterified cr-linolenic acid and linoleic acid with a ratio of 1:4 (SR-3) were evaluated in four rat models of epileptic seizures: (1) i.p. injection of a single convulsant dose (50 mg/kg or 100 mg/kg) of pentylenetetrazol; (2) repeated subconvulsant doses of pentylenetetrazol; (3) cortical irritation by intraventricular administration of iron chloride (FeCl3); and (4) audiogenic seizure-prone preparation created by repeated pretreatment with p-cresol. Treatment with SR-3 (about 40 mg/kg i.p.) for a period of 3 weeks prior to challenge was found effective in each of these experimental models and caused up to a 22-fold increase in latency to major motor seizures, up to 84% reduction in the number of rats with seizures, and up to a 97% reduction in the duration of seizures. It is postulated that the anticonvulsant effects of SR-3 may be related to its stabilization of neuronal membranes. SR-3 should be evaluated further as a treatment for epilepsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:13:19