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Titolo:
RAT PRL AND TSH SECRETION ARE REGULATED DIFFERENTLY BY K-CHANNEL BLOCKERS()
Autore:
WANG XB; INUKAI T; GREER MA; GREER SE;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT MED,ENDOCRINOL SECT PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT MED,ENDOCRINOL SECT PORTLAND OR 97201
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 266, anno: 1994,
parte:, 1
pagine: 50000039 - 50000043
SICI:
0002-9513(1994)266:1<50000039:RPATSA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; PANCREATIC B-CELLS; POTASSIUM CHANNELS; PROLACTIN SECRETION; PITUITARY-CELLS; CALCIUM INFLUX; LACTOTROPH CELLS; LINE GH3; DOPAMINE; SOMATOSTATIN;
Keywords:
EXOCYTOSIS; ION CHANNELS; DOPAMINE; TRANSDUCTION MECHANISMS; TETRAETHYLAMMONIUM; PROLACTIN; THYROID-STIMULATING HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
X.B. Wang et al., "RAT PRL AND TSH SECRETION ARE REGULATED DIFFERENTLY BY K-CHANNEL BLOCKERS()", The American journal of physiology, 266(1), 1994, pp. 50000039-50000043

Abstract

All four different K+-channel blockers [tetraethylammonium (TEA), a nonselective K+-channel blocker; tolbutamide, an ATP-sensitive K+-channel blocker; quinine and 4-aminopyridine, both primarily voltage-dependent K+-channel blockers] stimulated prolactin (Prl) secretion by acutely dispersed anterior pituitary cells but had no effect on thyroid-stimulating hormone (TSH) secretion. TEA stimulated Prl secretion in a dose-dependent manner between 1 mu M and 20 mM, but even as high srs 20 mM, TEA did not induce TSH secretion. Valinomycin (2 mu M), a K+ ionophore, inhibited both basal and TEA-induced Prl secretion. TEA-stimulated Prl secretion was abolished by using a Ca2+-depleted medium or adding 10 mu M dopamine. TEA. did not reverse the inhibitory effect of dopamine on thyrotropin-releasing hormone-induced Prl secretion. Our dataindicate that K+ channels may play a role in the secretion of adenohypophysial hormones that is idiosyncratic for each hormone. Differencesin the role of K+ channels may reflect differences between the various pituitary cell types in plasma membrane ion channel composition, membrane potential, or the mechanism of exocytosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:15:00