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Titolo:
A PLACEBO-CONTROLLED COMPARATIVE-EVALUATION OF DICLOFENAC DISPERSIBLEVERSUS IBUPROFEN IN POSTOPERATIVE PAIN AFTER 3RD MOLAR SURGERY
Autore:
BAKSHI R; FRENKEL G; DIETLEIN G; MEURERWITT B; SCHNEIDER B; SINTERHAUF U;
Indirizzi:
CIBA GEIGY AG,DEPT MED,KLYBECKSTR CH-4002 BASEL SWITZERLAND CIBA GEIGY LTD,CTR DENT ORAL & MAXILLOFACIAL DIS FRANKFURT GERMANY CIBA GEIGY LTD,DEPT MED FRANKFURT GERMANY
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 3, volume: 34, anno: 1994,
pagine: 225 - 230
SICI:
0091-2700(1994)34:3<225:APCODD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER WISDOM TOOTH; SURGICAL REMOVAL; DENTAL PAIN; SODIUM; EFFICACY; RELIEF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R. Bakshi et al., "A PLACEBO-CONTROLLED COMPARATIVE-EVALUATION OF DICLOFENAC DISPERSIBLEVERSUS IBUPROFEN IN POSTOPERATIVE PAIN AFTER 3RD MOLAR SURGERY", Journal of clinical pharmacology, 34(3), 1994, pp. 225-230

Abstract

The analgesic efficacy of single oral doses of drinkable diclofenac dispersible 50 mg was compared with that of ibuprofen 400 mg and placebo in a randomized, double-blind, parallel-group trial in 257 adult patients (245 valid for efficacy) with severe postoperative pain after extraction of an impacted lower third molar. In this study, pain intensity (on a 100-mm visual analog scale) and pain relief from baseline (using a five-point verbal rating scale) were assessed serially during anobservation period of a hours. Intake of rescue analgesic was permitted in case of insufficient therapeutic effect; however at least 1 hourshould have elapsed after test drug consumption. On the main efficacyvariable, namely, reduction in the pain intensity score, both diclofenac dispersible (n = 83) and ibuprofen (n = 80) were statistically significantly (P <.01) superior to placebo (n = 82) starting at 20 and 40minutes, respectively, after drug intake. The active medications werealso significantly (P <.01) better than placebo for the secondary efficacy parameters viz. summed pain relief scores over 6 hours (TOTPAR-6); frequency of remedication with a rescue analgesic in the three treatment groups (diclofenac, 24%; ibuprofen, 28%; placebo, 65%); mean time to remedication; and global evaluation. All the treatments were welltolerated. Thus assay sensitivity of this trial (ibuprofen significantly better than placebo) has been demonstrated; in addition, diclofenac as a dispersible formulation has been shown to be an effective analgesic for the treatment of post-surgical dental pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:31:04