Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
METAANALYSIS OF ALL AVAILABLE PUBLISHED CLINICAL-TRIALS (1958-1990) ON THROMBOLYTIC THERAPY FOR AMI - RELATIVE EFFICACY OF DIFFERENT THERAPEUTIC STRATEGIES
Autore:
GRUNEWALD M; SEIFRIED E;
Indirizzi:
UNIV ULM,DEPT INTERNAL MED 3 W-7900 ULM GERMANY RED CROSS,DONOR SERV,CENT INST FRANKFURT GERMANY
Titolo Testata:
Fibrinolysis
fascicolo: 2, volume: 8, anno: 1994,
pagine: 67 - 86
SICI:
0268-9499(1994)8:2<67:MOAAPC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; TISSUE PLASMINOGEN-ACTIVATOR; LEFT-VENTRICULAR FUNCTION; LUMINAL CORONARY ANGIOPLASTY; DOSE INTRAVENOUS STREPTOKINASE; PROSPECTIVE RANDOMIZED TRIAL; PLACEBO-CONTROLLED TRIAL; INTRACORONARY FIBRINOLYTIC THERAPY; UNIVERSITY REPERFUSION TRIAL; 12-MONTH FOLLOW-UP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
396
Recensione:
Indirizzi per estratti:
Citazione:
M. Grunewald e E. Seifried, "METAANALYSIS OF ALL AVAILABLE PUBLISHED CLINICAL-TRIALS (1958-1990) ON THROMBOLYTIC THERAPY FOR AMI - RELATIVE EFFICACY OF DIFFERENT THERAPEUTIC STRATEGIES", Fibrinolysis, 8(2), 1994, pp. 67-86

Abstract

Data of approximately 100000 acute myocardial infarction (AMI) patients, having been treated in 300 clinical trials on thrombolysis for AMI, were included in a meta-analysis comparing the relative efficacy of currently employed plasminogen activators and investigating the influence of early versus late initiation of conjunctive heparin therapy. Early patency after thrombolysis with novel plasminogen activators or intracoronary lysis was significantly higher in comparison with standardstreptokinase; this superiority however, did translate into significantly lower mortality rates only for rt-PA. Early initiation of heparinanticoagulation exerted only little influence on early patency, whichappears to be determined by the thrombolytic strategy. Reocclusion rates showed a weak correlation with patency; a clear reduction of reocclusion rates was seen when heparin was initiated early. Cumulative in-hospital mortality rates ranged from 4% to 9%. The effects of heparin on mortality were variable; a statistically significant reduction of mortality was noted after rt-PA but not after streptokinase and APSAC, when early versus late conjunctive heparin was compared. Early initiation of anticoagulant therapy is mandatory after thrombolysis with rt-PA; the time of initiation of prophylactic anticoagulation after streptokinase or APSAC did not influence the outcome significantly. Thrombolytic therapy with i.v. rt-PA proved to be superior to all other thrombolytic strategies currently employed, provided, an effective antithrombotic treatment is coadministered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:50:41