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Titolo:
ANGIOTENSINOGEN AS A RISK FACTOR FOR ESSENTIAL-HYPERTENSION IN JAPAN
Autore:
HATA A; NAMIKAWA C; SASAKI M; SATO K; NAKAMURA T; TAMURA K; LALOUEL JM;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PUBL HLTH,KITA KU,KITA 15 JYO NISHI 7 CHOME SAPPORO HOKKAIDO 070 JAPAN NAGOYA CITY UNIV,SCH MED,DEPT BIOCHEM,MIZUHO KU NAGOYA AICHI 467 JAPAN NAGOYA CITY UNIV,SCH MED,DEPT INTERNAL MED,MIZUHO KU NAGOYA AICHI 467JAPAN YAMANASHI MED UNIV,DEPT INTERNAL MED TAMAHO YAMANASHI 40938 JAPAN UNIV UTAH,SCH MED,HOWARD HUGHES MED INST SALT LAKE CITY UT 84112 UNIV UTAH,SCH MED,DEPT HUMAN GENET SALT LAKE CITY UT 84112
Titolo Testata:
The Journal of clinical investigation
fascicolo: 3, volume: 93, anno: 1994,
pagine: 1285 - 1287
SICI:
0021-9738(1994)93:3<1285:AAARFF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; SODIUM;
Keywords:
HYPERTENSION; GENETICS, JAPAN; ANGIOTENSINOGEN; GENETIC MARKER;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A. Hata et al., "ANGIOTENSINOGEN AS A RISK FACTOR FOR ESSENTIAL-HYPERTENSION IN JAPAN", The Journal of clinical investigation, 93(3), 1994, pp. 1285-1287

Abstract

A common molecular variant of angiotensinogen (AGT), the precursor ofthe potent vasoactive hormone angiotensin II, has been incriminated as a marker for a genetic predisposition to essential hypertension in Caucasians (Jeunemaitre, X., F. Soubrier, Y. V. Kotelevtsev, R. P. Lifton, C. S. Williams, A. Charru, S. C. Hunt, P. N. Hopkins, R. R. Williams, J. M. Lalouel, and P. Corvol. 1992. Cell. 71:169-180). We now showthat the same variant, T235, is associated with essential hypertension in Japanese patients. The observation of this association in a distinct, ethnically homogeneous population further substantiates an involvement of angiotensinogen in the pathogenesis of essential hypertensionand has physiological, epidemiological, and evolutionary implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:37:53