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Titolo:
THE EVOLUTION OF TITIN AND RELATED GIANT MUSCLE PROTEINS
Autore:
HIGGINS DG; LABEIT S; GAUTEL M; GIBSON TJ;
Indirizzi:
EUROPEAN MOLEC BIOL LAB,POSTFACH 102209,MEYERHOFSTR 1 D-69012 HEIDELBERG GERMANY
Titolo Testata:
Journal of molecular evolution
fascicolo: 4, volume: 38, anno: 1994,
pagine: 395 - 404
SICI:
0022-2844(1994)38:4<395:TEOTAR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT CHAIN KINASE; MOLECULAR-WEIGHT PROTEINS; SEQUENCE; DOMAIN; CDNA; IDENTIFICATION; DROSOPHILA; EXPRESSION; PROJECTIN; TWITCHIN;
Keywords:
TITIN; TWITCHIN; MUSCLE; MYOSIN LIGHT-CHAIN KINASE; IMMUNOGLOBULIN C2 DOMAIN; FIBRONECTIN CLASS III DOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Higgins et al., "THE EVOLUTION OF TITIN AND RELATED GIANT MUSCLE PROTEINS", Journal of molecular evolution, 38(4), 1994, pp. 395-404

Abstract

Titin and twitchin are giant proteins expressed in muscle. They are mainly composed of domains belonging to the fibronectin class III and immunoglobulin c2 families, repeated many times. In addition, both proteins have a protein kinase domain near the C-terminus. This paper explores the evolution of these and related muscle proteins in an attempt to determine the order of events that gave rise to the different repeat patterns and the order of appearance of the proteins. Despite their great similarity at the level of sequence organization, titin and twitchin diverged from each other at least as early as the divergence between vertebrates and nematodes. Most of the repeating units in titin and twitchin were estimated to derive from three original domains. Chicken smooth-muscle myosin light-chain kinase (smMLCK) also has a kinase domain, several immunoglobulin domains, and a fibronectin domain. Froma comparison of the kinase domains, titin is predicted to have appeared first during the evolution of the family, followed by twitchin and with the vertebrate MLCKs last to appear. The so-called C-protein fromchicken is also a member of this family but has no kinase domain. Itsorigin remains unclear but it most probably pre-dates the titin/twitchin duplication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:46:05