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Titolo:
CHARACTERIZATION OF THE GENE ENCODING THE HUMAN TRANSCRIPTIONAL ELONGATION-FACTOR TFIIS
Autore:
PARK HR; BAEK KH; JEON CJ; AGARWAL K; YOO OJ;
Indirizzi:
KYUNGHEE UNIV,DEPT GENET ENGN SUWON 449701 SOUTH KOREA KYUNGHEE UNIV,DEPT GENET ENGN SUWON 449701 SOUTH KOREA KOREA ADV INST SCI & TECHNOL,DEPT LIFE SCI TAEJON 305701 SOUTH KOREA KYUNGHEE UNIV,INST GENET ENGN SUWON 449701 SOUTH KOREA UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL CHICAGO IL 60637
Titolo Testata:
Gene
fascicolo: 2, volume: 139, anno: 1994,
pagine: 263 - 267
SICI:
0378-1119(1994)139:2<263:COTGET>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA POLYMERASE-II; FACTOR-S-II; SACCHAROMYCES-CEREVISIAE; DNA-SEQUENCE; C-MYC; TERMINATION; EXPRESSION; PROTEIN; CLONING; INVITRO;
Keywords:
INTRON-LESS; PSEUDOGENE; ANTITERMINATION; ALU SEQUENCE; RNA POLYMERASE II;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Park et al., "CHARACTERIZATION OF THE GENE ENCODING THE HUMAN TRANSCRIPTIONAL ELONGATION-FACTOR TFIIS", Gene, 139(2), 1994, pp. 263-267

Abstract

The transcriptional elongation factor TFIIS causes stimulation of RNApolymerase II elongation and readthrough of some of the elongation blocks. We present cloning and sequence characterization of the human TFIIS gene and a pseudogene. The intron-less organization of both of these genes indicates that previously identified cDNAs which suggested the presence of an intron were the products of cloning artifacts. The gene is organized in an uninterrupted ORF which codes for 301 amino acids, whereas the pseudogene lacks an ORF able to code for a full-length protein. The potential promoter for the gene has two putative GC-box-type consensus sequences, two CCAAT-box consensus sequences, and is bounded by a human Alu sequence. Two potential transcriptional termination signal sequences downstream from the consensus polyadenylation signal are proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:20:39