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Titolo:
NEUROCOGNITIVE DEFICITS AND NEUROLOGICAL SIGNS IN SCHIZOPHRENIA
Autore:
WONG AHC; VORUGANTI LNP; HESLEGRAVE RJ; AWAD AG;
Indirizzi:
CLARKE INST PSYCHIAT,ROOM 722,250 COLL ST TORONTO ON M5T 2R8 CANADA UNIV WESTERN ONTARIO,DEPT PSYCHIAT TORONTO ON CANADA
Titolo Testata:
Schizophrenia research
fascicolo: 2, volume: 23, anno: 1997,
pagine: 139 - 146
SICI:
0920-9964(1997)23:2<139:NDANSI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYNDROME SCALE; SOFT SIGNS; NEUROLEPTIC-NAIVE; ABNORMALITIES; DYSFUNCTION; DISTURBANCE; PERFORMANCE; DISCORDANT; INPATIENTS; IMPAIRMENT;
Keywords:
SCHIZOPHRENIA; NEUROLOGICAL SIGNS; COGNITIVE DEFICITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A.H.C. Wong et al., "NEUROCOGNITIVE DEFICITS AND NEUROLOGICAL SIGNS IN SCHIZOPHRENIA", Schizophrenia research, 23(2), 1997, pp. 139-146

Abstract

Objective: This is a comprehensive study designed to examine the association between specific clusters of neurological abnormalities and several clinically relevant aspects of schizophrenia such as positive and negative symptoms, neurocognitive deficits and psychosocial performance. Methods: Thirty-seven clinically stable schizophrenic (DSM-III-R)patients maintained on antipsychotic medication were comprehensively examined and Convit's Quantified Neurologic Scale (QNS) was completed. In addition, patients' psychopathology was rated on the Positive and Negative Syndromes Scale (PANSS); psychosocial performance was rated on the Global Scale of Adaptive Functioning (GAF) and the Social Performance Schedule (SPS); and neurocognitive deficits were measured with acomputer-assisted neurocognitive test battery, COGLAB. The association between these factors was determined using Pearson's correlation coefficients. Results: Frontal and soft neurological scores on the QNS correlated significantly with negative syndrome scores (r=0.45-0.51, p<0.05) and general psychopathology scores (r=0.46-0.49, p<0.02) on PANSS; poor psychosocial performance on GAF (r = 0.43-0.56, p < 0.02) and SPS (r = 0.37-0.54, p < 0.007); and performance on the span of apprehension (r=0.48-0.74, p<0.0001), backward masking (r=0.34-0.54, p<0.01) and Wisconsin card sorting (r=0.48-0.67, p <0.001) tasks. Conclusion: Frontal and soft neurological signs in schizophrenic patients are associated with prominent negative symptoms, relatively poor psychosocial performance and significantly more cognitive impairment. Past research has associated soft neurological signs, cognitive impairment and structural brain abnormalities with poor outcome and prognosis in patients with schizophrenia.

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Documento generato il 31/03/20 alle ore 15:20:16