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Titolo:
ROSTROCAUDAL SUBREGIONAL DIFFERENCES IN THE RESPONSE OF ENKEPHALIN, DYNORPHIN AND SUBSTANCE-P SYNTHESIS IN RAT NUCLEUS-ACCUMBENS TO DOPAMINE DEPLETION
Autore:
VOORN P; DOCTER GJ; JONGENRELO AL; JONKER AJ;
Indirizzi:
FREE UNIV AMSTERDAM,FAC MED,NEUROSCI RES INST,DEPT ANAT & EMBRYOL,VANDER BOECHORSTSTR 7 1081 BT AMSTERDAM NETHERLANDS
Titolo Testata:
European journal of neuroscience
fascicolo: 3, volume: 6, anno: 1994,
pagine: 486 - 496
SICI:
0953-816X(1994)6:3<486:RSDITR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS LEUCOAGGLUTININ; PREPROENKEPHALIN MESSENGER-RNA; VENTRAL STRIATUM; BASAL GANGLIA; TOPOGRAPHICAL ORGANIZATION; PROJECTION NEURONS; INVIVO RELEASE; FRONTAL-CORTEX; RECEPTOR GENE; EXPRESSION;
Keywords:
BASAL GANGLIA; STRIATUM; OPIOID PEPTIDES; TACHYKININ; 6-HYDROXYDOPAMINE LESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
P. Voorn et al., "ROSTROCAUDAL SUBREGIONAL DIFFERENCES IN THE RESPONSE OF ENKEPHALIN, DYNORPHIN AND SUBSTANCE-P SYNTHESIS IN RAT NUCLEUS-ACCUMBENS TO DOPAMINE DEPLETION", European journal of neuroscience, 6(3), 1994, pp. 486-496

Abstract

Quantitative in situ hybridization histochemistry was used to examinethe effects of unilateral 6-hydroxydopamine lesions of the ascending dopaminergic fibres on levels of mRNA encoding the neuropeptides enkephalin, dynorphin and substance P in subregions of the nucleus accumbens. The nucleus accumbens was divided into quadrants and changes in mRNA were measured along the rostrocaudal extent of the nucleus. Two weeks after the lesion an increase was found in enkephalin mRNA in the lesioned side compared to the non-lesioned side, whereas a decrease was observed for dynorphin and substance P mRNA. The changes in mRNA levelsdiffered from quadrant to quadrant and were not uniformly distributedalong the rostrocaudal axis. Both types of changes, i.e. increase anddecrease, were much higher in rostral parts of the nucleus than in caudal parts, indicating regional differences in the effects of blockadeof the dopaminergic neurotransmission. The lesion-induced increases and decreases in mRNA levels occurred in both the shell and the core subregions of the nucleus accumbens and were not specifically related toeither of these areas. Factors are discussed that may contribute to the rostrocaudal gradient in the changes of enkephalin, substance P anddynorphin mRNA levels. On the basis of their afferent and efferent connections, the rostral and caudal parts of the nucleus accumbens are considered to be involved in different functions. The present results suggest that dopamine depletion may affect these functions in a differential manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:22:12