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Titolo:
EFFECTS OF ENDOTHELIN-1 ON ISOLATED UTERINE HORNS IN ESTROGEN-PRIMED AND PREGNANT MICE
Autore:
GONG QY; CHEN LA; LI JZ; XU WH; YANG ZC;
Indirizzi:
SHANGHAI MED UNIV,SCH BASIC MED SCI,DEPT PHARMACOL SHANGHAI 200032 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 2, volume: 15, anno: 1994,
pagine: 129 - 132
SICI:
0253-9756(1994)15:2<129:EOEOIU>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM; MYOMETRIUM; PEPTIDE; UTERUS;
Keywords:
ENDOTHELINS; OXYTOCIN; CARBOPROST; UTERINE CONTRACTION; ANIMAL PREGNANCY; DRUG DOSE-RESPONSE RELATIONSHIP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
Q.Y. Gong et al., "EFFECTS OF ENDOTHELIN-1 ON ISOLATED UTERINE HORNS IN ESTROGEN-PRIMED AND PREGNANT MICE", Zhongguo yaoli xuebao, 15(2), 1994, pp. 129-132

Abstract

Mouse uterine horns from 4 states (estrogen-primed and early-, mid-, and late-pregnancy) were used to study the effect of endothelin-1 (ET)vs carboprost (Car) and oxytocin (Oxy). In K+-Krebs (KCl 40 mmol.L(-1)) solution, ET (1-300 nmol.L(-1)), Car (0.002-20 mu mol.L(-1)), and Oxy (0.6-60 nmol.L(-1)) evoked concentration-dependent increases in tension of the uterine horns from 4 different states. E(max) for ET were 1.12+/-0.26, 1.27+/-0.18 and 1.49+/-0.13 g in early-, mid-, and late-pregnancies, respectively. E(max) for Car in mid- was twice that in late-pregnancy, whereas E(max) for Oxy in late- was thrice that in mid-pregnancy. EC(50) for ET were 9.6, 5.8, and 6.3 nmol.L(-1) in early-, mid-, and late-pregnancies, respectively, and were only 2% to 7% of thatfor Car and 3-15 times of that for Oxy in various gravid stages. The results suggest that the contractile activity of pregnant mouse uterusto ET is more potent than that of Car while slightly weaker than thatof Oxy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 20:16:18