Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE MYB AND AHI-1 GENES ARE PHYSICALLY VERY CLOSELY LINKED ON MOUSE CHROMOSOME-10
Autore:
JIANG X; VILLENEUVE L; TURMEL C; KOZAK CA; JOLICOEUR P;
Indirizzi:
CLIN RES INST MONTREAL,MOLEC BIOL LAB,110 PINE AVE W MONTREAL H2W 1R7PQ CANADA CLIN RES INST MONTREAL,MOLEC BIOL LAB MONTREAL H2W 1R7 PQ CANADA XEROX RES CTR CANADA LTD MISSISSAUGA L5K 2L1 ON CANADA NIAID,MOLEC MICROBIOL LAB BETHESDA MD 20892 MCGILL UNIV,DEPT EXPTL MED MONTREAL H3G 1A4 PQ CANADA UNIV MONTREAL,DEPT MICROBIOL & IMMUNOL MONTREAL H3C 3J7 PQ CANADA
Titolo Testata:
Mammalian genome
fascicolo: 3, volume: 5, anno: 1994,
pagine: 142 - 148
SICI:
0938-8990(1994)5:3<142:TMAAGA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE LEUKEMIA-VIRUS; T-CELL LYMPHOMAS; FIELD GEL-ELECTROPHORESIS; ABELSON VIRUS; C-MYB; PROVIRUS INTEGRATION; NUCLEOTIDE-SEQUENCE; VIRAL INTEGRATION; RAT THYMOMAS; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
X. Jiang et al., "THE MYB AND AHI-1 GENES ARE PHYSICALLY VERY CLOSELY LINKED ON MOUSE CHROMOSOME-10", Mammalian genome, 5(3), 1994, pp. 142-148

Abstract

Ahi-1 has previously been identified as a common helper provirus integration site on mouse Chromosome (Chr) 10 in 16% of Abelson pre-B-celllymphomas and shown to be closely linked to the Myb protooncogene. Byusing long-range restriction mapping, we have mapped the Myb and Ahi-1 regions within a 120-kbp DNA fragment. The Ahi-1 region is located approximately 35 kbp downstream of the Myb gene. A further comfirmationof this finding was obtained by screening a mouse YAC library. The three positive clones obtained contained both the Myb and Ahi-1 gene sequences. To test whether provirus integration in the Ahi-1 region enhances the expression of Myb by a cis-acting mechanism, we have also examined Myb gene expression in A-MuLV-induced pre-B-lymphomas. Our data have revealed that there is no clear evidence for such activation in the tumors we have tested, indicating that provirus insertion in the Ahi-1 region is activating a novel gene, apparently involved in tumor formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:03:37