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Titolo:
PLASMA ATRIAL-NATRIURETIC-FACTOR IN OBESITY - CORRELATION TO ECHOCARDIOGRAPHY
Autore:
ABDELHAFEZ MA; NASR S; ELGHAZALY S; ABDELGHANY N; OKASHA S; ELMOLLA B;
Indirizzi:
CAIRO UNIV,FAC MED,DEPT BIOCHEM,KASR EL AINI CAIRO EGYPT CAIRO UNIV,FAC MED,DEPT INTERNAL MED CAIRO EGYPT
Titolo Testata:
Journal of clinical biochemistry and nutrition
fascicolo: 1, volume: 16, anno: 1994,
pagine: 59 - 66
SICI:
0912-0009(1994)16:1<59:PAIO-C>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR GENE; EXPRESSION; HEART; HYPERTROPHY; VENTRICLES; TISSUE; RATS;
Keywords:
ATRIAL NATRIURETIC FACTOR; ECHOCARDIOGRAPHY; HYPERTENSION; IMPAIRED LEFT VENTRICULAR FUNCTION; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Abdelhafez et al., "PLASMA ATRIAL-NATRIURETIC-FACTOR IN OBESITY - CORRELATION TO ECHOCARDIOGRAPHY", Journal of clinical biochemistry and nutrition, 16(1), 1994, pp. 59-66

Abstract

The plasma levels of atrial natriuretic factor (ANF), renin activity and aldosterone level in a lean control group (group I, n = 20), obesenormotensive individuals (group II, n = 46), and obese hypertensives (group III, n = 14) were estimated along with echocardiographic examination. According to findings obtained from echocardiography, normotensive and hypertensive obese subjects with impaired left ventricular diastolic function were subclassified as groups IIa and IIIa, respectively. ANF was found to be increased in obese normotensive and obese hypertensive groups compared with the control group level. Obese normotensive and obese hypertensive subjects with impaired left ventricular function were found to have higher plasma ANF than their unimpaired counterparts. An inverse relation was found between plasma ANF and plasma renin activity or aldosterone level. There were a significant decrease in fractional shortening and increase in left atrial diameter in groupsIIa and IIIa compared with control group. We conclude that impairmentof the left ventricular diastolic function caused by hypertrophy of the left ventricle in obese normotensives and obese hypertensives produces elevation of pressure in the left atrium and an increase in the secretion of ANF. Cardiac chamber in pressure is a reflection of this increased circulating ANF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:19:15