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Titolo:
HEPATIC VECTORIAL TRANSPORT OF XENOBIOTICS
Autore:
LEBLANC GA;
Indirizzi:
N CAROLINA STATE UNIV,DEPT TOXICOL,BOX 7633 RALEIGH NC 27695
Titolo Testata:
Chemico-biological interactions
fascicolo: 2, volume: 90, anno: 1994,
pagine: 101 - 120
SICI:
0009-2797(1994)90:2<101:HVTOX>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-BINDING-PROTEIN; GLUTATHIONE S-TRANSFERASES; ATP-DEPENDENT TRANSPORT; MULTIDRUG-RESISTANT CELLS; CANALICULAR MEMBRANE-VESICLES; CYCLICAL OXIDATION REDUCTION; CARRIER-MEDIATED TRANSPORT; CULTURED RAT HEPATOCYTES; LIVER PLASMA-MEMBRANES; HIGH-AFFINITY BINDING;
Keywords:
TRANSPORT; TRANSFER; XENOBIOTICS; INFLUX; EFFLUX; LIVER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
146
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Leblanc, "HEPATIC VECTORIAL TRANSPORT OF XENOBIOTICS", Chemico-biological interactions, 90(2), 1994, pp. 101-120

Abstract

The vectorial transport of xenobiotics across the hepatocyte is mediated by various transport and transfer proteins that differ in ligand specificity and function. The influx of xenobiotics from the blood across the sinusoidal membrane of the hepatocyte can occur through passiveor active transport processes. Once in the cell, xenobiotics can be sequestered by intracellular transfer proteins that prevent refluxing of the chemical back through the sinusoidal membrane. Transfer proteinsmay also facilitate the localization of the xenobiotics within the cell to sites of metabolism (i.e., the endoplasmic reticulum) or elimination (i.e., the canalicular membrane). Intracellular transfer proteinsinclude glutathione S-transferases, fatty acid-binding proteins, and 3alpha-hydroxysteroid dehydrogenase. Intracellular nuclear transfer proteins have also been identified that facilitate the transfer of chemical carcinogens from the cytoplasm into the cell nucleus. Several active transport proteins exist on the canalicular membrane of the hepatocyte that mediate the efflux of chemicals from the cell into the biliary canaliculus. Xenobiotic efflux proteins include the multispecific organic anion transporter, that eliminates xenobiotics that have undergone conjugation with glutathione, glucuronic acid, and possibly sulfate; and, P-glycoprotein, an active transporter that actively effluxes a variety of structurally diverse xenobiotics. Induction of P-glycoprotein by the amplification of its gene has been identified as a major cause of resistance of tumor cells to the toxicity of a variety of anti-cancer drugs. The hepatic induction of P-glycoprotein may also contribute to acquired resistance of organisms to environmental toxicants. Continued elucidation of xenobiotic transport and transfer processes at the cellular levels will significantly advance our understanding of processes involved in xenobiotic toxicity and acquired resistance to chemical toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:42:36