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Titolo:
PATTERN OF NERVOUS-TISSUE IMMUNOSTAINING BY HUMAN ANTI-GLYCOLIPID ANTIBODIES
Autore:
NARDELLI E; ANZINI P; MORETTO G; RIZZUTO N; STECK AJ;
Indirizzi:
UNIV VERONA,POLICLIN BORGO ROMA,IST NEUROL I-37134 VERONA ITALY UNIV BASEL CLIN,DEPT NEUROL BASEL SWITZERLAND
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 122, anno: 1994,
pagine: 220 - 227
SICI:
0022-510X(1994)122:2<220:PONIBH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NEURON DISEASE; GANGLIOSIDES GM1; MONOCLONAL IGM; CHOLERA-TOXIN; SPINAL-CORD; LOCALIZATION; SERA; GD1B; AUTOANTIBODIES; IMMUNOGLOBULIN;
Keywords:
ANTI-GM1 ANTIBODIES; ANTI-SULFATIDE ANTIBODIES; IMMUNOCYTOCHEMISTRY; GRAY MATTER; DORSAL ROOT GANGLIA; SUBSTANTIA-GELATINOSA; MOTOR NEURON; NODE OF RANVIER; PEANUT AGGLUTININ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
E. Nardelli et al., "PATTERN OF NERVOUS-TISSUE IMMUNOSTAINING BY HUMAN ANTI-GLYCOLIPID ANTIBODIES", Journal of the neurological sciences, 122(2), 1994, pp. 220-227

Abstract

Immunostaining of human, bovine and rodent unfixed nervous tissue sections was performed in order to characterize the structures recognizedby anti-glycolipid antibodies. Four human sera from patients, two with M-IgM and motor neuron syndrome or motor neuropathy and two with motor neuropathy and polyclonal IgG antibody activity against gangliosides (GL; i.e. GM1, GD1b, GD1a), were utilized. Serum from a patient withsensory neuropathy and M-IgM immunoglobulins with antibody activity against sulfatide (SUL) was included in this series. This study shows that polyclonal and monoclonal anti-glycolipid antibodies give three different patterns of staining. The first is cholera toxin-like showing a more restricted neuronal pattern of staining. The second is peanut agglutinin-like, which includes the carbohydrate epitope shared by a group of glycoproteins in the gray and white matter. The third (anti-SUL) gives a preferential myelin staining. However, sera with anti-GM1 and anti-SUL antibodies recognize a number of closely situated determinants in the gray matter of the spinal cord and in the granule cells, while in peripheral nerves or in neuronal cells in culture their bindingproduces a different pattern (nodes of Ranvier for anti-GL; myelin for anti-SUL). These findings indicate that immunohistochemistry with anti-GL and anti-SUL antibodies may provide information regarding the glycolipid-bearing anatomical structures as target antigens and further substantiate the role of these molecules in the pathogenesis of autoimmune neurological disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:20:10