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Titolo:
CARPAL AND TARSAL BONE ANOMALIES IN MICE INDUCED BY MATERNAL TREATMENT OF ARA-C
Autore:
RAHMAN ME; ISHIKAWA H; WATANABE Y; ENDO A;
Indirizzi:
YAMAGATA UNIV,SCH MED,DEPT HYG & PREVENT MED YAMAGATA 99023 JAPAN YAMAGATA UNIV,SCH MED,DEPT HYG & PREVENT MED YAMAGATA 99023 JAPAN YAMAGATA UNIV,SCH MED,DEPT ORTHOPED SURG YAMAGATA 99023 JAPAN
Titolo Testata:
Reproductive toxicology
fascicolo: 1, volume: 8, anno: 1994,
pagine: 41 - 47
SICI:
0890-6238(1994)8:1<41:CATBAI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOSINE-ARABINOSIDE; MOUSE EMBRYOS; SKELETON; DIFFERENTIATION; MATINGS; DEFECTS; PERIOD; RAT;
Keywords:
CARPAL AND TARSAL BONE ANOMALIES; FUSION; ABSENCE; DEFORMATION; ARA-C; CYTOSINE ARABINOSIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Rahman et al., "CARPAL AND TARSAL BONE ANOMALIES IN MICE INDUCED BY MATERNAL TREATMENT OF ARA-C", Reproductive toxicology, 8(1), 1994, pp. 41-47

Abstract

Pregnant mice of the Jcl:ICR strain were injected intraperitoneally with a single dose of 5 mg/kg of cytosine arabinoside (Ara-C) on dg 10.5. Skeletal changes of the forepaw and hindpaw were evaluated in the offspring on the 15th or 24th postnatal day. Various anomalies of carpal and tarsal bones such as fusion, absence, and deformation occurred at high incidence at a dose that produced digital anomalies. Almost allnewborns with Ara-C-induced digital anomalies (oligodactyly or polydactyly) had anomalies of carpal or tarsal bones in the particular paw, while anomalies of carpal or tarsal bones could occur in the presence or absence of digital anomalies. Carpal and tarsal bone anomalies may become a sensitive and novel parameter of limb development in the postnatal teratogen testing system.

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Documento generato il 02/12/20 alle ore 06:38:04