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Titolo:
IN-VIVO MICRODIALYSIS OF CORTICOTROPIN-RELEASING FACTOR (CRF) - CALCIUM-DEPENDENCE OF DEPOLARIZATION-INDUCED NEUROSECRETION OF CRF
Autore:
GABR RW; GLADFELTER WE; BIRKLE DL; AZZARO AJ;
Indirizzi:
W VIRGINIA UNIV,ROBERT C BYRD HLTH SCI CTR,DEPT NEUROL MORGANTOWN WV 26506 W VIRGINIA UNIV,ROBERT C BYRD HLTH SCI CTR,DEPT NEUROL MORGANTOWN WV 26506 W VIRGINIA UNIV,ROBERT C BYRD HLTH SCI CTR,DEPT BEHAV MED PSYCHIAT MORGANTOWN WV 26506 W VIRGINIA UNIV,ROBERT C BYRD HLTH SCI CTR,DEPT PHARMACOL TOXICOL MORGANTOWN WV 26506 W VIRGINIA UNIV,ROBERT C BYRD HLTH SCI CTR,DEPT PHYSIOL MORGANTOWN WV26506
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 169, anno: 1994,
pagine: 63 - 67
SICI:
0304-3940(1994)169:1-2<63:IMOCF(>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-LIKE IMMUNOREACTIVITY; RAT-BRAIN REGIONS; HORMONE-SECRETION; MEDIAN-EMINENCE; MOVING RATS; INVITRO; HYPOTHALAMUS; VASOPRESSIN; AMYGDALA; URETHANE;
Keywords:
MICRODIALYSIS; MEDIAN EMINENCE; NEUROPEPTIDE; HYPOTHALAMUS; NEUROENDOCRINE; CRF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Gabr et al., "IN-VIVO MICRODIALYSIS OF CORTICOTROPIN-RELEASING FACTOR (CRF) - CALCIUM-DEPENDENCE OF DEPOLARIZATION-INDUCED NEUROSECRETION OF CRF", Neuroscience letters, 169(1-2), 1994, pp. 63-67

Abstract

Corticotropin releasing factor (CRF) is a large neuropeptide which functions as a major neurotransmitter in physiological stress responses. We have developed a microdialysis method for detecting CRF release from the median eminence of anesthetized rats. Depolarizing concentrations of KCl increased release of CRF into the perfusion media; this effect was inhibited by 100 muM verapamil. Our characterization of the physiologic conditions of KCl-induced release of neuronal CRF using the microdialysis technique provides evidence that the CRF release system is Ca2+-dependent and maintains its integrity over many hours in anesthetized rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:50:33