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Titolo:
IMPAIRED NEUROGENESIS BY METHYLAZOXYMETHANOL IN NEWBORN RATS RESULTS IN TRANSIENT REDUCTION OF ORNITHINE DECARBOXYLASE AND POLYAMINES IN THE CEREBELLUM, BUT NOT IN THE OLFACTORY BULBS
Autore:
FACCHINETTI F; CIANI E; SPARAPANI M; BARNABEI O; CONTESTABILE A;
Indirizzi:
UNIV BOLOGNA,DEPT BIOL I-40126 BOLOGNA ITALY UNIV BOLOGNA,DEPT BIOL I-40126 BOLOGNA ITALY
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 1, volume: 12, anno: 1994,
pagine: 19 - 24
SICI:
0736-5748(1994)12:1<19:INBMIN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; BRAIN; INDUCTION; ACTIVATION; ABLATION; STRIATUM; NEURONS; LESIONS; INJURY; ACID;
Keywords:
ORNITHINE DECARBOXYLASE; POLYAMINES; IMPAIRED NEUROGENESIS; METHYLAZOXYMETHANOL ACETATE; CEREBELLUM; OLFACTORY BULBS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
F. Facchinetti et al., "IMPAIRED NEUROGENESIS BY METHYLAZOXYMETHANOL IN NEWBORN RATS RESULTS IN TRANSIENT REDUCTION OF ORNITHINE DECARBOXYLASE AND POLYAMINES IN THE CEREBELLUM, BUT NOT IN THE OLFACTORY BULBS", International journal of developmental neuroscience, 12(1), 1994, pp. 19-24

Abstract

Polyamines and the key enzyme for their biosynthesis, ornithine decarboxylase (ODC) play an important role in the control of neuronal proliferation and differentiation. Exposure to agents that interfere with normal cell maturation is expected to result in alteration of neuronal ODC developmental pattern. We have administered to newborn rats, about6 and 30 hr after birth, 20 mg/kg of methylazoxymethanol acetate (MAM), an agent able to selectively kill dividing cells and we have evaluated ODC activity and polyamine levels in the cerebellum and ODC activity in the olfactory bulbs at various developmental stages starting from postnatal day 4 (PD 4) until PD 28. Cerebellar weight decreased by 22-50% at the different developmental stages in MAM-treated animals. A decline in OD C specific activity was observed at PD 4 and a decrease of putrescine levels at PD 4 and PD 6 in the cerebellum. At PD 10, however, both ODC activity and putrescine level were increased in MAM-treated animals. Spermidine levels were never affected by the treatment, while spermine was significantly decreased at PD 6 and PD 8. These results demonstrate that altered ontogenetic patterns of ODC activity andpolyamine levels are the consequence of disturbance of the normal process of brain maturation. No significant differences in specific ODC activity were noticed in the olfactory bulbs of MAM-treated rats. This may be related to the more widespread time-span of neurogenesis in this region, a fact that is also revealed by the higher ODC activity constitutively expressed at times in which neurogenesis has ended in the rest of the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 03:47:50