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Titolo:
NICOTINE INCREASES SENSORY GATING MEASURED AS INHIBITION OF THE ACOUSTIC STARTLE REFLEX IN RATS
Autore:
ACRI JB; MORSE DE; POPKE EJ; GRUNBERG NE;
Indirizzi:
US FDA,DIV ANTIVIRAL DRUP PROD,HFD-530,5600 FISHERS LANE ROCKVILLE MD20857 US FDA,DIV ANTIVIRAL DRUP PROD ROCKVILLE MD 20857 UNIFORMED SERV UNIV HLTH SCI,DEPT MED PSYCHOL BETHESDA MD 20814
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 114, anno: 1994,
pagine: 369 - 374
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; D-AMPHETAMINE; AUTORADIOGRAPHIC DISTRIBUTION; ALZHEIMERS-DISEASE; DOPAMINE; SCHIZOPHRENICS; FACILITATION; APOMORPHINE; PERFORMANCE; STIMULATION;
Keywords:
NICOTINE; ACOUSTIC STARTLE REFLEX (ASR); SENSORY GATING; PRE-PULSE INHIBITION (PPI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Acri et al., "NICOTINE INCREASES SENSORY GATING MEASURED AS INHIBITION OF THE ACOUSTIC STARTLE REFLEX IN RATS", Psychopharmacology, 114(2), 1994, pp. 369-374

Abstract

Chronic nicotine administration has been reported to increase acoustic startle response (ASR) amplitude in rats, which has been offered as evidence that some dosages of nicotine can enhance attention. The present experiments examined effects of acutely administered nicotine on amplitude and pre-pulse inhibition (PPI) of acoustic startle in rats. PPI, the decrease in ASR amplitude by a stimulus preceding the startle-eliciting event, reflects pre-attentive neural processes underlying sensory gating. Nicotine had a biphasic dose effect on startle amplitude, with increases at lower dosages (0.01 mg/kg) and decreases at higherdosages (0.5-5.0 mg/kg SC). Lower dosages of nicotine (0.001-0.01 mg/kg) increased PPI and the increase at 0.001 mg/kg occurred independently of changes in ASR amplitude. These results confirm that increases in PPI are not dependent upon changes in ASR amplitude. Results are consistent with nicotine's enhancements of performance on cognitive tasksin humans and are the first reported use of the PPI paradigm to modelsuch effects. These findings indicate that ASR paradigms are useful to study effects of nicotine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:43:45