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Titolo:
ONCOSTATIN-M, LEUKEMIA INHIBITORY FACTOR, AND INTERLEUKIN-6 INDUCE THE PROLIFERATION OF HUMAN PLASMACYTOMA CELLS VIA THE COMMON SIGNAL TRANSDUCER, GP130
Autore:
NISHIMOTO N; OGATA A; SHIMA Y; TANI Y; OGAWA H; NAKAGAWA M; SUGIYAMA H; YOSHIZAKI K; KISHIMOTO T;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT MED 3,2-2 YAMADA OKA SUITA OSAKA 565 JAPAN
Titolo Testata:
The Journal of experimental medicine
fascicolo: 4, volume: 179, anno: 1994,
pagine: 1343 - 1347
SICI:
0022-1007(1994)179:4<1343:OLIFAI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MYELOMA CELLS; MULTIPLE-MYELOMA; MOLECULAR-CLONING; GROWTH-FACTOR; BONE-MARROW; EXPRESSION; IDENTIFICATION; CYTOKINES; RECEPTOR; DIFFERENTIATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N. Nishimoto et al., "ONCOSTATIN-M, LEUKEMIA INHIBITORY FACTOR, AND INTERLEUKIN-6 INDUCE THE PROLIFERATION OF HUMAN PLASMACYTOMA CELLS VIA THE COMMON SIGNAL TRANSDUCER, GP130", The Journal of experimental medicine, 179(4), 1994, pp. 1343-1347

Abstract

We analyzed the stimulatory effect of oncostatin M (OSM), leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and the inhibitoryeffect of anti-IL-6 antibody (Ab), anti-IL-6 receptor monoclonal antibody (mAb), and anti-gp130 mAb on the growth of human plasmacytoma cells freshly isolated from a patient with multiple myeloma. The purifiedcells showed a plasmacytoid morphology and expressed CD38, CD54, and CD56 antigens but no CD3, CD5, CD10, CD19, CD20, or very late antigen 5. IL-6 receptor (IL-6R) and its signal transducer, gp130, were expressed on their cell surface at a low level. Dose-dependent proliferationof the cells in response to OSM, LIF, and IL-6, but not to IL-11, wasobserved using [H-3]TdR incorporation in vitro. Both anti-IL-6 Ab andanti-IL-6R mAb inhibited the growth of the cells in the presence or absence of exogenous IL-6. These cells release IL-6 but not OSM or LIF into the culture supernatant during short-term culture. Therefore, an autocrine growth mechanism mediated by IL-6, but not by OSM or LIF, was confirmed. Furthermore, anti-gp130 mAb completely inhibited the proliferation of the cells induced by OSM, LIF, as well as IL-6. These data indicate that OSM, LIF, and IL-6 can act as growth factors of human plasmacytoma cells through a common signal transducer, gp130, on theircell surface, and also suggest the potential therapeutic application of anti-gp130 mAb, as well as anti-IL-6R mAb against myeloma/plasmacytomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:33:48