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Titolo:
FURTHER ASSESSMENT OF THE PROTECTIVE EFFECT OF CALMODULIN INHIBITORS AGAINST REPERFUSION INJURY AFTER ACUTE CORONARY-OCCLUSION IN THE DOG
Autore:
GABAUER I; SLEZAK J; STYK J; ZIEGELHOFFER A;
Indirizzi:
SLOVAK ACAD SCI,INST HEART RES,DUBRAVSKA CESTA 9 CS-84233 BRATISLAVA SLOVAKIA SLOVAK ACAD SCI,INST HEART RES,DUBRAVSKA CESTA 9 CS-84233 BRATISLAVA SLOVAKIA
Titolo Testata:
Canadian journal of cardiology
fascicolo: 1, volume: 10, anno: 1994,
pagine: 125 - 132
SICI:
0828-282X(1994)10:1<125:FAOTPE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Keywords:
CALMODULIN INHIBITORS; CHLORPROMAZINE; CORONARY OCCLUSION; REPERFUSION INJURY; TRIFLUOPERAZINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
I. Gabauer et al., "FURTHER ASSESSMENT OF THE PROTECTIVE EFFECT OF CALMODULIN INHIBITORS AGAINST REPERFUSION INJURY AFTER ACUTE CORONARY-OCCLUSION IN THE DOG", Canadian journal of cardiology, 10(1), 1994, pp. 125-132

Abstract

OBJECTIVE: To re-evaluate the suitability of chlorpromazine and trifluoperazine to prevent postischemic reperfusion injury of the myocardium. DESIGN: Acute occlusion (60 mins) and subsequent reperfusion (120 mins) of the left anterior descendent coronary artery with monitoring of hemodynamic, morphological and biochemical variables of the heart. SETTING: Experimental study. ANIMALS: Seventy adult mongrel dogs. INTERVENTIONS: Chlorpromazine (15 mg/kg body weight) or trifluoperazine (2 mg/kg body weight) given intravenously 30 mins after the onset of occlusion. MAIN RESULTS: Reperfusion alone increased the regional bloodflow and left ventricular end-diastolic pressure (P<0.05 to 0.01), and reduced the size of the occluded area. Reperfusion also decreased the dp/dt(max), V(max), mean aortic pressure, cardiac index, etc, but failedto improve cardiac ultrastructure and metabolism. Chlorpromazine or trifluoperazine induced a further reduction (P<0.05 to 0.01) in infarctsize, left ventricular end-diastolic pressure and systemic resistanceindex, and caused an increase in dp/dt(max), V(max), cardiac index and regional bloodflow in the ischemic and border zones of the left ventricle. Moreover, these drugs preserved, to a certain extent, the metabolism of the myocardium and its ultrastructure. CONCLUSIONS: In spite of their considerable preventive effect, neither chlorpromazine nor trifluoperazine provided a complete prevention of reperfusion injury to the myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:55:16