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Titolo:
LYMPHOCYTE SUBPOPULATIONS, INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR EXPRESSION IN CHILDHOOD NEPHROTIC SYNDROME
Autore:
HULTON SA; SHAH V; BYRNE MR; MORGAN G; BARRATT TM; DILLON MJ;
Indirizzi:
CHILDRENS HOSP,DEPT NEPHROL,MED UNIT,LADYWOOD MIDDLEWAY BIRMINGHAM B16 8ET W MIDLANDS ENGLAND INST CHILD HLTH,DIV MED,MED UNIT LONDON WC1N 1EH ENGLAND INST CHILD HLTH,DIV CELL & MOLEC BIOL IMMUNOL LONDON WC1N 1EH ENGLAND
Titolo Testata:
Pediatric nephrology
fascicolo: 2, volume: 8, anno: 1994,
pagine: 135 - 139
SICI:
0931-041X(1994)8:2<135:LSIAIR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Keywords:
NEPHROTIC SYNDROME; LYMPHOCYTE; INTERLEUKIN-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Hulton et al., "LYMPHOCYTE SUBPOPULATIONS, INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR EXPRESSION IN CHILDHOOD NEPHROTIC SYNDROME", Pediatric nephrology, 8(2), 1994, pp. 135-139

Abstract

Abnormal T lymphocyte function and reduced interleukin-2 (IL-2) production have been implicated in the pathogenesis of the nephrotic syndrome (NS). We investigated: (1) lymphocyte subpopulations and expressionof IL-2 receptor (IL-2R) on T cells using two-colour flow cytometry, (2) serum IL-2 and (3) the soluble component of IL-2R (sIL-2R) in serum, using enzyme-linked immunosorbent assay, in 38 children with NS. All children, except those in remission, had marked proteinuria. They were divided into groups according to renal pathology: (1) steroid-sensitive NS (SSNS) not receiving prednisolone therapy, (2) SSNS on prednisolone, (3) focal segmental glomerulosclerosis (FSGS), (4) SSNS in remission and not receiving prednisolone therapy, (5) congenital NS (CNS). Results were compared with 26 age-matched controls. Total T lymphocytes (CD3) were reduced in groups 1 and 2; CD4 count was reduced in groups 1-4; CD8 count increased in groups 2 and 3; CD8 and CD19 (B lymphocytes) were significantly reduced in group 5. Increased IL-2R expression (CD25) on CD4 lymphocytes was noted in groups 1, 2 and 3 implying activation of these cells. In patients with SSNS, increased serum sIL-2Rwas recorded during relapse (1,273 +/- 497 U/l vs. 913 +/- 401 U/l inremission, P <0.005) but free serum IL-2 was not detectable at any stage. The specific alterations in lymphocyte subpopulations in SSNS andFSGS would imply an involvement of the immune system distinct from that in CNS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 03:37:46