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Titolo:
RELATIONSHIP BETWEEN HOMOZYGOSITY AT THE DOPAMINE D3 RECEPTOR GENE AND SCHIZOPHRENIA
Autore:
MANT R; WILLIAMS J; ASHERSON P; PARFITT E; MCGUFFIN P; OWEN MJ;
Indirizzi:
UNIV WALES COLL CARDIFF,COLL MED,DEPT PSYCHOL MED,HEATH PK CARDIFF CF4 4XN S GLAM WALES UNIV WALES COLL CARDIFF,COLL MED,DEPT PSYCHOL MED CARDIFF CF4 4XN S GLAM WALES UNIV WALES COLL CARDIFF,COLL MED,DEPT MED GENET CARDIFF S GLAM WALES
Titolo Testata:
American journal of medical genetics
fascicolo: 1, volume: 54, anno: 1994,
pagine: 21 - 26
SICI:
0148-7299(1994)54:1<21:RBHATD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLONING; LOCALIZATION; ASSOCIATION; AFFINITY;
Keywords:
BAL I POLYMORPHISM; DOPAMINE D3 RECEPTOR GENE; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R. Mant et al., "RELATIONSHIP BETWEEN HOMOZYGOSITY AT THE DOPAMINE D3 RECEPTOR GENE AND SCHIZOPHRENIA", American journal of medical genetics, 54(1), 1994, pp. 21-26

Abstract

We have reported an association between schizophrenia and homozygosity of a Bal I polymorphism in the first exon of the dopamine D3 receptor gene (Crocq et al.: Journal of Medical Genetics 29:858-860, 1992). The present study consists of an attempt to replicate this finding in afurther sample of 66 patients and 97 controls. Once again more patients than controls were homozygous, but the effect was not as strong as in our first study (chi(2) = 2.53, P = 0.05, one tailed). When pooled data from our two studies were analysed, excess homozygosity in patients remained highly significant (P = 0.002) with a particular excess ofthe 1:1 genotype (P = 0.01). This reflected a departure from Hardy-Weinberg equilibrium in the patients (P = 0.0005) but not the controls (P = 0.24). This led us to explore the possibility that there might be important differences between the patients in our two studies and thatexcess homozygosity might be a characteristic of particular subgroupsof schizophrenics. Our findings suggest that the effect is consistently at its strongest in those patients who have a high familial loadingand in those who have a good response to neuroleptic treatment, and that differences between our two samples might have contributed to the quantitatively different outcomes. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:34:36